I propose to continue along the path of my prior work in cancer epidemiology. That work will entail: 1) Analyses of routinely-collected data on cancer incidence. Local and national data will be used, both to generate clues as to the etiologies of cancer and to address practical issues of cancer prevention. 2) Cohort and population-based case-control studies of cancer. In addition to concluding a number of studies begun during the first cycle of funding from the Outstanding Investigator Grant, I plan to initiate others, likely including studies of: a) ovarian cancer in relation to galactose consumption and metabolism; and b) subsequent cancer incidence among women with infertility, with particular attention given to the type of infertility and its treatment. With colleagues in the laboratory, I will continue to explore ways of more precisely characterizing exposure or susceptibility that can be put to use in epidemiologic studies. 3) Refinement of epidemiologic methods relevant to the study of cancer. Emphasis will be given to development of analytic strategies to minimize bias in case-control studies which evaluate the efficacy of cancer screening modalities.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
5R35CA039779-09
Application #
3479005
Study Section
Special Emphasis Panel (SRC (88))
Project Start
1985-07-01
Project End
1999-04-30
Budget Start
1993-05-01
Budget End
1994-04-30
Support Year
9
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of Washington
Department
Type
Schools of Public Health
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195
Prescott, Jennifer; Setiawan, Veronica W; Wentzensen, Nicolas et al. (2015) Body Mass Index Genetic Risk Score and Endometrial Cancer Risk. PLoS One 10:e0143256
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Doherty, Jennifer A; Weiss, Noel S; Fish, Sherianne et al. (2011) Polymorphisms in nucleotide excision repair genes and endometrial cancer risk. Cancer Epidemiol Biomarkers Prev 20:1873-82

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