The planned studies will be a continuation of ongoing projects that reflect a long interest in abnormal growth regulation in the human hematopoietic system. 1. Combined chromosomal and molecular studies, with Dr. Carlo Croce and others, of specific genes involved in human lymphoid and myeloid neoplasms and mechanisms leading to altered gene function. 2. Longitudinal cytogenetic studies in chronic B cell and T cell disorders correlated with clinical, biological, and immunological characteristics of these neoplasms. 3. Further investigation of altered growth regulation in chronic B cell and T cell disorders, including inhibitory factors (transforming growth factor-beta), stimulatory factors, and the role of autoreactivity in B-CLL. (This grant is a component of the University of Pennsylvania Cancer Center)

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
5R35CA042232-13
Application #
2667889
Study Section
Special Emphasis Panel (SRC (88))
Program Officer
Taube, Sheila E
Project Start
1986-05-10
Project End
2000-02-29
Budget Start
1998-03-01
Budget End
1999-02-28
Support Year
13
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Pathology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
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