Abstract

1. Lymphocyte differentiation antigens: gene cloning, regulation and function 2. Immunoglobulin genetics, structure and function 3. B and T cell subset definitions, development, lineages and functions 4. Development of fluorescence activated cell sorting Overall, we hope to understand the molecules and cells of the immune system: how they develop, interact, are regulated, function, and result in immune disorders and malignancies when they malfunction. Novel interspecific chimeric antibodies and site-specific mutated antibodies will be explored for reduced immunogenecity for use as therapeutic agents and for structure/function understanding.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
5R35CA042509-05
Application #
3479343
Study Section
Special Emphasis Panel (SRC)
Project Start
1986-07-01
Project End
1993-06-30
Budget Start
1990-07-01
Budget End
1991-06-30
Support Year
5
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
Schools of Medicine
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Fong, Lawrence; Mengozzi, Manuela; Abbey, Nancy W et al. (2002) Productive infection of plasmacytoid dendritic cells with human immunodeficiency virus type 1 is triggered by CD40 ligation. J Virol 76:11033-41
De Rosa, S C; Mitra, D K; Watanabe, N et al. (2001) Vdelta1 and Vdelta2 gammadelta T cells express distinct surface markers and might be developmentally distinct lineages. J Leukoc Biol 70:518-26
De Rosa, S C; Herzenberg, L A; Herzenberg, L A et al. (2001) 11-color, 13-parameter flow cytometry: identification of human naive T cells by phenotype, function, and T-cell receptor diversity. Nat Med 7:245-8
Tjioe, I; Legerton, T; Wegstein, J et al. (2001) Phycoerythrin-allophycocyanin: a resonance energy transfer fluorochrome for immunofluorescence. Cytometry 44:24-9
Nakamura, H; Herzenberg, L A; Bai, J et al. (2001) Circulating thioredoxin suppresses lipopolysaccharide-induced neutrophil chemotaxis. Proc Natl Acad Sci U S A 98:15143-8
Mengozzi, M; Malipatlolla, M; De Rosa, S C et al. (2001) Naive CD4 T cells inhibit CD28-costimulated R5 HIV replication in memory CD4 T cells. Proc Natl Acad Sci U S A 98:11644-9
Salomon, A R; Voehringer, D W; Herzenberg, L A et al. (2001) Apoptolidin, a selective cytotoxic agent, is an inhibitor of F0F1-ATPase. Chem Biol 8:71-80
Torres-Roca, J F; Tung, J W; Greenwald, D R et al. (2000) An early oxygen-dependent step is required for dexamethasone-induced apoptosis of immature mouse thymocytes. J Immunol 165:4822-30
De Rosa, S C; Zaretsky, M D; Dubs, J G et al. (2000) N-acetylcysteine replenishes glutathione in HIV infection. Eur J Clin Invest 30:915-29
Salomon, A R; Voehringer, D W; Herzenberg, L A et al. (2000) Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F(0)F(1)-ATPase. Proc Natl Acad Sci U S A 97:14766-71

Showing the most recent 10 out of 83 publications