Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
5R35CA044353-10
Application #
2091441
Study Section
Special Emphasis Panel (SRC (88))
Project Start
1987-09-30
Project End
2001-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Biochemistry
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Kim, H-J; Lee, S-B; Guengerich, F P et al. (2007) Effects of N-terminal modification of recombinant human cytochrome P450 1A2 on catalytic activity. Xenobiotica 37:356-65
Velez-Cruz, Renier; Riggins, James N; Daniels, J Scott et al. (2005) Exocyclic DNA lesions stimulate DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells. Biochemistry 44:3972-81
Guengerich, F Peter (2005) Principles of covalent binding of reactive metabolites and examples of activation of bis-electrophiles by conjugation. Arch Biochem Biophys 433:369-78
Kim, Donghak; Guengerich, F Peter (2005) Cytochrome P450 activation of arylamines and heterocyclic amines. Annu Rev Pharmacol Toxicol 45:27-49
Guengerich, F Peter; Krauser, Joel A; Johnson, William W (2004) Rate-limiting steps in oxidations catalyzed by rabbit cytochrome P450 1A2. Biochemistry 43:10775-88
Guengerich, F Peter (2004) Cytochrome P450: what have we learned and what are the future issues? Drug Metab Rev 36:159-97
Kim, Eun-Young; Kim, Joon-Sik; Kim, Min-Young et al. (2004) Non-specific inhibition of human cytochrome P450-catalyzed reactions by hemin. Toxicol Lett 153:239-46
Peter Guengerich, F; Chun, Young-Jin; Kim, Donghak et al. (2003) Cytochrome P450 1B1: a target for inhibition in anticarcinogenesis strategies. Mutat Res 523-524:173-82
Guengerich, F Peter (2003) Activation of dihaloalkanes by thiol-dependent mechanisms. J Biochem Mol Biol 36:20-7
Yun, Chul-Ho; Lee, Hye Suk; Lee, Hee-Yong et al. (2003) Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin. Toxicol Lett 137:143-50

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