Abstract

I propose to continue our work in cancer epidemiology that has developed at the Kaiser Permanente Medical Care Program in the past 1 1/2 decades and has been supported for 4 years by an Outstanding Investigators Grant, as follows: 1. Continue surveillance for possible carcinogenic effects of medicinal drugs in a cohort of 143,574 Kaiser Foundation Health Plan members using additional data resources of the program to test hypotheses. Study newer drugs, as appropriate, using the new region-wide pharmacy data system that is currently being implemented. 2. Continue follow-up of a cohort of over 100,000 persons who received multiphasic health checkups plus research questionnaires on smoking and alcohol use, to study cancer-producing effects of various tobacco products, alcoholic beverages, marijuana and other factors. 3. Continue to conduct nested case-control studies of possible chemopreventive factors in the above multiphasic cohort using a large collection of frozen serum specimens. 4. Continue to conduct studies of the efficacy of screening tests in preventing mortality from cancer. 5. Employ the flexibility afforded by the Outstanding Investigator Grant to study promising new leads concerning cancer etiology and control in the extensive data resources of Kaiser Permanente.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Unknown (R35)
Project #
2R35CA049761-06
Application #
2093435
Study Section
Special Emphasis Panel (SRC (90))
Project Start
1989-06-01
Project End
2001-03-31
Budget Start
1994-06-15
Budget End
1995-03-31
Support Year
6
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Kaiser Foundation Research Institute
Department
Type
DUNS #
City
Oakland
State
CA
Country
United States
Zip Code
94612

  Publications

Haselkorn, Tmirah; Whittemore, Alice S; Udaltsova, Natalia et al. (2006) Short-term chloral hydrate administration and cancer in humans. Drug Saf 29:67-77
Efird, Jimmy T; Friedman, Gary D; Sidney, Stephen et al. (2004) The risk for malignant primary adult-onset glioma in a large, multiethnic, managed-care cohort: cigarette smoking and other lifestyle behaviors. J Neurooncol 68:57-69
Witherell, Heidi L; Smith, Karen L; Friedman, Gary D et al. (2003) C-reactive protein, Helicobacter pylori, Chlamydia pneumoniae, cytomegalovirus and risk for myocardial infarction. Ann Epidemiol 13:170-7
Efird, Jimmy Thomas; Friedman, Gary D; Habel, Laurel et al. (2002) Risk of subsequent cancer following invasive or in situ squamous cell skin cancer. Ann Epidemiol 12:469-75
Herrinton, L J; Voigt, L F; Weiss, N S et al. (2001) Risk factors for synchronous primary endometrial and ovarian cancers. Ann Epidemiol 11:529-33
Small, R; Friedman, G D; Ettinger, B (2001) Concomitant medication use in postmenopausal women using estrogen therapy. Menopause 8:120-6
Iribarren, C; Friedman, G D; Klatsky, A L et al. (2001) Exposure to environmental tobacco smoke: association with personal characteristics and self reported health conditions. J Epidemiol Community Health 55:721-8
Iribarren, C; Haselkorn, T; Tekawa, I S et al. (2001) Cohort study of thyroid cancer in a San Francisco Bay area population. Int J Cancer 93:745-50
Shibata, A; Longacre, T A; Puligandla, B et al. (2001) Histological classification of gastric adenocarcinoma for epidemiological research: concordance between pathologists. Cancer Epidemiol Biomarkers Prev 10:75-8
Slattery, M L; Edwards, S L; Ma, K N et al. (2000) Colon cancer screening, lifestyle, and risk of colon cancer. Cancer Causes Control 11:555-63

Showing the most recent 10 out of 63 publications