Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37AA006603-11
Application #
3479905
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1991-09-01
Project End
1994-06-30
Budget Start
1993-12-01
Budget End
1994-06-30
Support Year
11
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
She, Hongyun; Xiong, Shigang; Hazra, Saswati et al. (2005) Adipogenic transcriptional regulation of hepatic stellate cells. J Biol Chem 280:4959-67
Deng, Qing-Gao; She, Hongyun; Cheng, Jason H et al. (2005) Steatohepatitis induced by intragastric overfeeding in mice. Hepatology 42:905-14
Sung, Chin K; She, Hongyun; Xiong, Shigang et al. (2004) Tumor necrosis factor-alpha inhibits peroxisome proliferator-activated receptor gamma activity at a posttranslational level in hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol 286:G722-9
Hazra, Saswati; Xiong, Shigang; Wang, Jiaohong et al. (2004) Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. J Biol Chem 279:11392-401
Veal, Nary; Hsieh, Chih-Lin; Xiong, Shigang et al. (2004) Inhibition of lipopolysaccharide-stimulated TNF-alpha promoter activity by S-adenosylmethionine and 5'-methylthioadenosine. Am J Physiol Gastrointest Liver Physiol 287:G352-62
Xiong, Shigang; She, Hongyun; Takeuchi, Heigo et al. (2003) Signaling role of intracellular iron in NF-kappaB activation. J Biol Chem 278:17646-54
Xiong, Shigang; She, Hongyun; Sung, Chin K et al. (2003) Iron-dependent activation of NF-kappaB in Kupffer cells: a priming mechanism for alcoholic liver disease. Alcohol 30:107-13
She, Hongyun; Xiong, Shigang; Lin, Min et al. (2002) Iron activates NF-kappaB in Kupffer cells. Am J Physiol Gastrointest Liver Physiol 283:G719-26
Tsukamoto, Hidekazu (2002) Iron regulation of hepatic macrophage TNFalpha expression. Free Radic Biol Med 32:309-13
Neuman, Manuela G; Katz, Gady G; Malkiewicz, Izabella M et al. (2002) Alcoholic liver injury and apoptosis--synopsis of the symposium held at ESBRA 2001: 8th Congress of the European Society for Biomedical Research on Alcoholism, Paris, September 16, 2001. Alcohol 28:117-28

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