Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37AG001228-16S1
Application #
2048630
Study Section
Special Emphasis Panel (NSS)
Project Start
1992-01-15
Project End
1996-11-30
Budget Start
1994-07-01
Budget End
1994-11-30
Support Year
16
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of Texas Sw Medical Center Dallas
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
City
Dallas
State
TX
Country
United States
Zip Code
75390
Robin, Jérôme D; Ludlow, Andrew T; Batten, Kimberly et al. (2015) SORBS2 transcription is activated by telomere position effect-over long distance upon telomere shortening in muscle cells from patients with facioscapulohumeral dystrophy. Genome Res 25:1781-90
Robin, Jérôme D; Ludlow, Andrew T; Batten, Kimberly et al. (2014) Telomere position effect: regulation of gene expression with progressive telomere shortening over long distances. Genes Dev 28:2464-76
Lue, Neal F; Chan, Jamie; Wright, Woodring E et al. (2014) The CDC13-STN1-TEN1 complex stimulates Pol ? activity by promoting RNA priming and primase-to-polymerase switch. Nat Commun 5:5762
Ludlow, Andrew T; Robin, Jerome D; Sayed, Mohammed et al. (2014) Quantitative telomerase enzyme activity determination using droplet digital PCR with single cell resolution. Nucleic Acids Res 42:e104
Stadler, Guido; Rahimov, Fedik; King, Oliver D et al. (2013) Telomere position effect regulates DUX4 in human facioscapulohumeral muscular dystrophy. Nat Struct Mol Biol 20:671-8
Chow, Tracy T; Zhao, Yong; Mak, Sabrina S et al. (2012) Early and late steps in telomere overhang processing in normal human cells: the position of the final RNA primer drives telomere shortening. Genes Dev 26:1167-78
Stewart, Jason A; Wang, Feng; Chaiken, Mary F et al. (2012) Human CST promotes telomere duplex replication and general replication restart after fork stalling. EMBO J 31:3537-49
Kim, Jinyong; Eskiocak, Ugur; Stadler, Guido et al. (2011) Short hairpin RNA screen indicates that Klotho beta/FGF19 protein overcomes stasis in human colonic epithelial cells. J Biol Chem 286:43294-300
Gomes, Nuno M V; Ryder, Oliver A; Houck, Marlys L et al. (2011) Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination. Aging Cell 10:761-8
Tennen, Ruth I; Bua, Dennis J; Wright, Woodring E et al. (2011) SIRT6 is required for maintenance of telomere position effect in human cells. Nat Commun 2:433

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