Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AG006173-21
Application #
7215320
Study Section
Special Emphasis Panel (NSS)
Program Officer
Snyder, Stephen D
Project Start
1985-09-01
Project End
2012-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
21
Fiscal Year
2007
Total Cost
$370,917
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Xu, Huixin; Rajsombath, Molly M; Weikop, Pia et al. (2018) Enriched environment enhances ?-adrenergic signaling to prevent microglia inflammation by amyloid-?. EMBO Mol Med 10:
Li, Shaomin; Jin, Ming; Liu, Lei et al. (2018) Decoding the synaptic dysfunction of bioactive human AD brain soluble A? to inspire novel therapeutic avenues for Alzheimer's disease. Acta Neuropathol Commun 6:121
Yang, Ting; Li, Shaomin; Xu, Huixin et al. (2017) Large Soluble Oligomers of Amyloid ?-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate. J Neurosci 37:152-163
Walsh, Dominic M; Selkoe, Dennis J (2016) A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration. Nat Rev Neurosci 17:251-60
Selkoe, Dennis J; Hardy, John (2016) The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO Mol Med 8:595-608
Jin, Ming; Selkoe, Dennis J (2015) Systematic analysis of time-dependent neural effects of soluble amyloid ? oligomers in culture and in vivo: Prevention by scyllo-inositol. Neurobiol Dis 82:152-163
Holmes, Oliver; Paturi, Swetha; Selkoe, Dennis J et al. (2014) Pen-2 is essential for ?-secretase complex stability and trafficking but partially dispensable for endoproteolysis. Biochemistry 53:4393-406
Muratore, Christina R; Rice, Heather C; Srikanth, Priya et al. (2014) The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons. Hum Mol Genet 23:3523-36
Morris, John C; Selkoe, Dennis J (2011) Recommendations for the incorporation of biomarkers into Alzheimer clinical trials: an overview. Neurobiol Aging 32 Suppl 1:S1-3
Shepardson, Nina E; Shankar, Ganesh M; Selkoe, Dennis J (2011) Cholesterol level and statin use in Alzheimer disease: I. Review of epidemiological and preclinical studies. Arch Neurol 68:1239-44

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