Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AG010885-16
Application #
7227993
Study Section
Special Emphasis Panel (NSS)
Program Officer
Murthy, Mahadev
Project Start
1992-08-01
Project End
2012-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
16
Fiscal Year
2007
Total Cost
$335,437
Indirect Cost
Name
University of Texas Medical Br Galveston
Department
Surgery
Type
Schools of Medicine
DUNS #
800771149
City
Galveston
State
TX
Country
United States
Zip Code
77555
Li, Jing; Song, Jun; Weiss, Heidi L et al. (2016) Activation of AMPK Stimulates Neurotensin Secretion in Neuroendocrine Cells. Mol Endocrinol 30:26-36
Li, Jing; Song, Jun; Zaytseva, Yekaterina Y et al. (2016) An obligatory role for neurotensin in high-fat-diet-induced obesity. Nature 533:411-5
Kim, Ji Tae; Li, Jing; Song, Jun et al. (2015) Differential expression and tumorigenic function of neurotensin receptor 1 in neuroendocrine tumor cells. Oncotarget 6:26960-70
Kim, Ji Tae; Liu, Chunming; Zaytseva, Yekaterina Y et al. (2015) Neurotensin, a novel target of Wnt/?-catenin pathway, promotes growth of neuroendocrine tumor cells. Int J Cancer 136:1475-81
Valentino, Joseph D; Li, Jing; Zaytseva, Yekaterina Y et al. (2014) Cotargeting the PI3K and RAS pathways for the treatment of neuroendocrine tumors. Clin Cancer Res 20:1212-22
Kim, Ji Tae; Li, Jing; Jang, Eun Ryoung et al. (2013) Deregulation of Wnt/?-catenin signaling through genetic or epigenetic alterations in human neuroendocrine tumors. Carcinogenesis 34:953-61
Li, Jing; Song, Jun; Cassidy, Margaret G et al. (2012) PI3K p110?/Akt signaling negatively regulates secretion of the intestinal peptide neurotensin through interference of granule transport. Mol Endocrinol 26:1380-93
Li, Jing; Liu, Jianyu; Song, Jun et al. (2011) mTORC1 inhibition increases neurotensin secretion and gene expression through activation of the MEK/ERK/c-Jun pathway in the human endocrine cell line BON. Am J Physiol Cell Physiol 301:C213-26
Wang, Xiaofu; Gulhati, Pat; Li, Jing et al. (2011) Characterization of promoter elements regulating the expression of the human neurotensin/neuromedin N gene. J Biol Chem 286:542-54
Silva, Scott R; Bowen, Kanika A; Rychahou, Piotr G et al. (2011) VEGFR-2 expression in carcinoid cancer cells and its role in tumor growth and metastasis. Int J Cancer 128:1045-56

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