Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37AG013939-12S2
Application #
7619321
Study Section
Special Emphasis Panel (NSS)
Program Officer
Snyder, Stephen D
Project Start
1996-09-19
Project End
2010-06-30
Budget Start
2008-05-15
Budget End
2008-06-30
Support Year
12
Fiscal Year
2008
Total Cost
$5,000
Indirect Cost

  Institution

Name
Northwestern University at Chicago
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611

  Publications

Barone, Eugenio; Di Domenico, Fabio; Sultana, Rukhsana et al. (2012) Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment. Free Radic Biol Med 52:2292-301
Sultana, Rukhsana; Robinson, Renã A S; Di Domenico, Fabio et al. (2011) Proteomic identification of specifically carbonylated brain proteins in APP(NLh)/APP(NLh) × PS-1(P264L)/PS-1(P264L) human double mutant knock-in mice model of Alzheimer disease as a function of age. J Proteomics 74:2430-40
Thompson, Wendy L; Van Eldik, Linda J (2009) Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-3 through NFkB and MAPK dependent pathways in rat astrocytes [corrected]. Brain Res 1287:47-57
Chico, Laura K; Van Eldik, Linda J; Watterson, D Martin (2009) Targeting protein kinases in central nervous system disorders. Nat Rev Drug Discov 8:892-909
Borders, Aaron S; de Almeida, Lucia; Van Eldik, Linda J et al. (2008) The p38alpha mitogen-activated protein kinase as a central nervous system drug discovery target. BMC Neurosci 9 Suppl 2:S12
Lloyd, Eric; Somera-Molina, Kathleen; Van Eldik, Linda J et al. (2008) Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury. J Neuroinflammation 5:28
Thompson, Wendy L; Karpus, William J; Van Eldik, Linda J (2008) MCP-1-deficient mice show reduced neuroinflammatory responses and increased peripheral inflammatory responses to peripheral endotoxin insult. J Neuroinflammation 5:35
Fuller, Abby D; Van Eldik, Linda J (2008) MFG-E8 regulates microglial phagocytosis of apoptotic neurons. J Neuroimmune Pharmacol 3:246-56
Van Eldik, Linda J; Thompson, Wendy L; Ralay Ranaivo, Hantamalala et al. (2007) Glia proinflammatory cytokine upregulation as a therapeutic target for neurodegenerative diseases: function-based and target-based discovery approaches. Int Rev Neurobiol 82:277-96
Wing, Laura K; Behanna, Heather A; Van Eldik, Linda J et al. (2006) De novo and molecular target-independent discovery of orally bioavailable lead compounds for neurological disorders. Curr Alzheimer Res 3:205-14

Showing the most recent 10 out of 50 publications