Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AG019391-19
Application #
9686644
Study Section
Special Emphasis Panel (NSS)
Program Officer
St Hillaire-Clarke, Coryse
Project Start
2015-04-01
Project End
2021-03-31
Budget Start
2019-04-01
Budget End
2021-03-31
Support Year
19
Fiscal Year
2019
Total Cost
Indirect Cost
Name
Weill Medical College of Cornell University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
060217502
City
New York
State
NY
Country
United States
Zip Code
10065
Carmo-Gonçalves, Phelippe; do Nascimento, Lucas Alex; Cortines, Juliana R et al. (2018) Exploring the role of methionine residues on the oligomerization and neurotoxic properties of DOPAL-modified ?-synuclein. Biochem Biophys Res Commun 505:295-301
Lima, Vanderlei de Araújo; do Nascimento, Lucas Alex; Eliezer, David et al. (2018) Role of Parkinson's Disease-Linked Mutations and N-Terminal Acetylation on the Oligomerization of ?-Synuclein Induced by 3,4-Dihydroxyphenylacetaldehyde. ACS Chem Neurosci :
Jentsch, Julian-Alexander; Kiburu, Irene; Pandey, Kalpana et al. (2018) Structural basis of sterol binding and transport by a yeast StARkin domain. J Biol Chem 293:5522-5531
Sung, Yoon-Hui; Eliezer, David (2018) Structure and dynamics of the extended-helix state of alpha-synuclein: Intrinsic lability of the linker region. Protein Sci 27:1314-1324
Lv, Guohua; Kumar, Ashutosh; Huang, Yun et al. (2018) A Protofilament-Protofilament Interface in the Structure of Mouse ?-Synuclein Fibrils. Biophys J 114:2811-2819
Eliezer, David (2017) Proteins acting out of (dis)order. Elife 6:
Ait-Bouziad, Nadine; Lv, Guohua; Mahul-Mellier, Anne-Laure et al. (2017) Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes. Nat Commun 8:1678
Wragg, Rachel T; Parisotto, Daniel A; Li, Zhenlong et al. (2017) Evolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins. Front Mol Neurosci 10:146
Villarreal-Ramirez, Eduardo; Eliezer, David; Garduño-Juarez, Ramon et al. (2017) Phosphorylation regulates the secondary structure and function of dentin phosphoprotein peptides. Bone 95:65-75
Snead, David; Lai, Alex L; Wragg, Rachel T et al. (2017) Unique Structural Features of Membrane-Bound C-Terminal Domain Motifs Modulate Complexin Inhibitory Function. Front Mol Neurosci 10:154

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