Abstract

Public Health Relevance

Loneliness is strongly predictive of decrements in health and increases in depressive symptomatology in spousal caregivers of patients with Alzheimer?s Disease (AD) as well as controls. To what extent loneliness is associated with adverse mental and physical health in AD patients is less clear in part because the validity of self-reports can be problematic in AD patients. The finding that loneliness is relatively stable in AD patients makes it possible to treat loneliness as a trait-like measure and investigate its predictive association with adverse outcomes such as the Conserved Transcriptional Response to Adversity (CTRA) that we have identified in monocytes in longitudinal studies in humans and in a monkey model as part of our ongoing R37.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Aging (NIA)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37AG033590-07S1
Application #
9308532
Study Section
Program Officer
Gerald, Melissa S
Project Start
2016-07-01
Project End
2017-02-28
Budget Start
2016-09-15
Budget End
2017-02-28
Support Year
7
Fiscal Year
2016
Total Cost
Indirect Cost

  Institution

Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637

  Publications

Abdellaoui, Abdel; Chen, Hsi-Yuan; Willemsen, Gonneke et al. (2018) Associations between loneliness and personality are mostly driven by a genetic association with Neuroticism. J Pers :
Abdellaoui, A; Nivard, M G; Hottenga, J-J et al. (2018) Predicting loneliness with polygenic scores of social, psychological and psychiatric traits. Genes Brain Behav 17:e12472
Cacioppo, John T; Cacioppo, Stephanie (2018) The Population-Based Longitudinal Chicago Health, Aging, and Social Relations Study (CHASRS): Study Description and Predictors of Attrition in Older Adults. Arch Sci Psychol 6:21-31
Mies, Gabry W; Verweij, Karin J H; Treur, Jorien L et al. (2018) Polygenic risk for alcohol consumption and its association with alcohol-related phenotypes: Do stress and life satisfaction moderate these relationships? Drug Alcohol Depend 183:7-12
Chun, K; Capitanio, J P; Lamkin, D M et al. (2017) Social regulation of the lymph node transcriptome in rhesus macaques (Macaca mulatta). Psychoneuroendocrinology 76:107-113
Gao, Jianjun; Davis, Lea K; Hart, Amy B et al. (2017) Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation. Neuropsychopharmacology 42:811-821
Capitanio, John P (2017) Naturally Occurring Nonhuman Primate Models of Psychosocial Processes. ILAR J 58:226-234
Mehl, Matthias R; Raison, Charles L; Pace, Thaddeus W W et al. (2017) Natural language indicators of differential gene regulation in the human immune system. Proc Natl Acad Sci U S A 114:12554-12559
Nagaraja, Archana S; Dood, Robert L; Armaiz-Pena, Guillermo et al. (2017) Adrenergic-mediated increases in INHBA drive CAF phenotype and collagens. JCI Insight 2:
Nagaraja, A S; Dorniak, P L; Sadaoui, N C et al. (2016) Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis. Oncogene 35:2390-7

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