Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI018045-25
Application #
6892861
Study Section
Special Emphasis Panel (NSS)
Program Officer
Hall, Robert H
Project Start
1981-07-01
Project End
2009-04-30
Budget Start
2005-05-01
Budget End
2006-04-30
Support Year
25
Fiscal Year
2005
Total Cost
$1,112,658
Indirect Cost
Name
Harvard University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115
Del Tordello, Elena; Danilchanka, Olga; McCluskey, Andrew J et al. (2016) Type VI secretion system sheaths as nanoparticles for antigen display. Proc Natl Acad Sci U S A 113:3042-7
Fu, Yang; Mekalanos, John J (2014) Infant Rabbit Colonization Competition Assays. Bio Protoc 4:
Ho, Brian T; Dong, Tao G; Mekalanos, John J (2014) A view to a kill: the bacterial type VI secretion system. Cell Host Microbe 15:9-21
Vercruysse, Maarten; Köhrer, Caroline; Davies, Bryan W et al. (2014) The highly conserved bacterial RNase YbeY is essential in Vibrio cholerae, playing a critical role in virulence, stress regulation, and RNA processing. PLoS Pathog 10:e1004175
Basler, Marek; Ho, Brian T; Mekalanos, John J (2013) Tit-for-tat: type VI secretion system counterattack during bacterial cell-cell interactions. Cell 152:884-94
Ho, Brian T; Basler, Marek; Mekalanos, John J (2013) Type 6 secretion system-mediated immunity to type 4 secretion system-mediated gene transfer. Science 342:250-3
Fu, Yang; Waldor, Matthew K; Mekalanos, John J (2013) Tn-Seq analysis of Vibrio cholerae intestinal colonization reveals a role for T6SS-mediated antibacterial activity in the host. Cell Host Microbe 14:652-63
Danilchanka, Olga; Mekalanos, John J (2013) Cyclic dinucleotides and the innate immune response. Cell 154:962-970
Basler, M; Pilhofer, M; Henderson, G P et al. (2012) Type VI secretion requires a dynamic contractile phage tail-like structure. Nature 483:182-6
Basler, M; Mekalanos, J J (2012) Type 6 secretion dynamics within and between bacterial cells. Science 337:815

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