Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI019428-14
Application #
2060928
Study Section
Special Emphasis Panel (NSS)
Project Start
1991-03-01
Project End
1997-02-28
Budget Start
1995-03-01
Budget End
1997-02-28
Support Year
14
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Picower Institute for Medical Research
Department
Type
DUNS #
City
Manhasset
State
NY
Country
United States
Zip Code
11030
Berger, B J; Suskin, M; Dai, W W et al. (1997) Studies on the pharmacological properties of novel arylene bis(methylketone) compounds using solid-phase extraction and high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 691:433-40
Berger, B J; Dai, W W; Cerami, A et al. (1997) Studies on the mechanism of antimalarial action of a novel arylene bis(methylketone). Biochem Pharmacol 54:739-42
Berger, B J; Paciorkowski, A; Suskin, M et al. (1996) Antimalarial activity of novel arylene bis(methylketone) compounds. J Infect Dis 174:659-62
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Field, H; Cerami, A; Henderson, G B (1992) Cloning, sequencing, and demonstration of polymorphism in trypanothione reductase from Crithidia fasciculata. Mol Biochem Parasitol 50:47-56
Fairlamb, A H; Cerami, A (1992) Metabolism and functions of trypanothione in the Kinetoplastida. Annu Rev Microbiol 46:695-729
Henderson, G B; Murgolo, N J; Kuriyan, J et al. (1991) Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction. Proc Natl Acad Sci U S A 88:8769-73
Kuriyan, J; Kong, X P; Krishna, T S et al. (1991) X-ray structure of trypanothione reductase from Crithidia fasciculata at 2.4-A resolution. Proc Natl Acad Sci U S A 88:8764-8
Henderson, G B; Ulrich, P; Fairlamb, A H et al. (1988) ""Subversive"" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease. Proc Natl Acad Sci U S A 85:5374-8
Henderson, G B; Fairlamb, A H; Ulrich, P et al. (1987) Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata. Biochemistry 26:3023-7

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