Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AI020248-22
Application #
6653652
Study Section
Special Emphasis Panel (NSS)
Program Officer
Gondre-Lewis, Timothy A
Project Start
1983-08-01
Project End
2008-01-31
Budget Start
2003-08-01
Budget End
2004-01-31
Support Year
22
Fiscal Year
2003
Total Cost
$259,000
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Pathology
Type
Schools of Medicine
DUNS #
603847393
City
Worcester
State
MA
Country
United States
Zip Code
01655
Colbert, Jeff D; Farfán-Arribas, Diego J; Rock, Kenneth L (2013) Substrate-induced protein stabilization reveals a predominant contribution from mature proteins to peptides presented on MHC class I. J Immunol 191:5410-9
Georgiadou, Dimitra; Hearn, Arron; Evnouchidou, Irini et al. (2010) Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1. J Immunol 185:1584-92
Rock, Kenneth L; Benacerraf, Baruj; Abbas, Abul K (2007) Pillars article: Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. 1984. J Immunol 179:7194-205
Mo, X Y; Cascio, P; Lemerise, K et al. (1999) Distinct proteolytic processes generate the C and N termini of MHC class I-binding peptides. J Immunol 163:5851-9
Vidard, L; Kovacsovics-Bankowski, M; Kraeft, S K et al. (1996) Analysis of MHC class II presentation of particulate antigens of B lymphocytes. J Immunol 156:2809-18
Falo Jr, L D; Kovacsovics-Bankowski, M; Thompson, K et al. (1995) Targeting antigen into the phagocytic pathway in vivo induces protective tumour immunity. Nat Med 1:649-53
Lah, T T; Hawley, M; Rock, K L et al. (1995) Gamma-interferon causes a selective induction of the lysosomal proteases, cathepsins B and L, in macrophages. FEBS Lett 363:85-9
Kovacsovics-Bankowski, M; Rock, K L (1995) A phagosome-to-cytosol pathway for exogenous antigens presented on MHC class I molecules. Science 267:243-6
Goldberg, A L; Gaczynska, M; Grant, E et al. (1995) Functions of the proteasome in antigen presentation. Cold Spring Harb Symp Quant Biol 60:479-90
Rock, K L; Gramm, C; Rothstein, L et al. (1994) Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules. Cell 78:761-71

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