Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI022021-21
Application #
6722783
Study Section
Special Emphasis Panel (NSS)
Program Officer
Klein, David L
Project Start
1984-07-01
Project End
2008-04-30
Budget Start
2004-05-01
Budget End
2005-04-30
Support Year
21
Fiscal Year
2004
Total Cost
$760,658
Indirect Cost
Name
Harvard University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115
Akkaladevi, Narahari; Mukherjee, Srayanta; Katayama, Hiroo et al. (2015) Following Natures Lead: On the Construction of Membrane-Inserted Toxins in Lipid Bilayer Nanodiscs. J Membr Biol 248:595-607
Jiang, Jiansen; Pentelute, Bradley L; Collier, R John et al. (2015) Atomic structure of anthrax protective antigen pore elucidates toxin translocation. Nature 521:545-9
Boland, Erin L; Van Dyken, Crystal M; Duckett, Rachel M et al. (2014) Structural complementation of the catalytic domain of pseudomonas exotoxin A. J Mol Biol 426:645-55
Sharma, Onkar; Collier, R John (2014) Polylysine-mediated translocation of the diphtheria toxin catalytic domain through the anthrax protective antigen pore. Biochemistry 53:6934-40
Akkaladevi, N; Hinton-Chollet, L; Katayama, H et al. (2013) Assembly of anthrax toxin pore: lethal-factor complexes into lipid nanodiscs. Protein Sci 22:492-501
McCluskey, Andrew J; Olive, Andrew J; Starnbach, Michael N et al. (2013) Targeting HER2-positive cancer cells with receptor-redirected anthrax protective antigen. Mol Oncol 7:440-51
Naik, Subhashchandra; Brock, Susan; Akkaladevi, Narahari et al. (2013) Monitoring the kinetics of the pH-driven transition of the anthrax toxin prepore to the pore by biolayer interferometry and surface plasmon resonance. Biochemistry 52:6335-47
McCluskey, Andrew J; Collier, R John (2013) Receptor-directed chimeric toxins created by sortase-mediated protein fusion. Mol Cancer Ther 12:2273-81
Gogol, E P; Akkaladevi, N; Szerszen, L et al. (2013) Three dimensional structure of the anthrax toxin translocon-lethal factor complex by cryo-electron microscopy. Protein Sci 22:586-94
Rodnin, Mykola V; Kyrychenko, Alexander; Kienker, Paul et al. (2011) Replacement of C-terminal histidines uncouples membrane insertion and translocation in diphtheria toxin T-domain. Biophys J 101:L41-3

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