Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AI023538-19
Application #
6822704
Study Section
Special Emphasis Panel (NSS)
Program Officer
Schmitt, Clare K
Project Start
1986-06-01
Project End
2010-05-31
Budget Start
2005-06-01
Budget End
2006-05-31
Support Year
19
Fiscal Year
2005
Total Cost
$367,875
Indirect Cost
Name
Tufts University
Department
Biochemistry
Type
Schools of Medicine
DUNS #
039318308
City
Boston
State
MA
Country
United States
Zip Code
02111
Mohammadi, Sina; Isberg, Ralph R (2013) Cdc42 interacts with the exocyst complex to promote phagocytosis. J Cell Biol 200:81-93
De Jesús, Dennise A; O'Connor, Tamara J; Isberg, Ralph R (2013) Analysis of Legionella infection using RNAi in Drosophila cells. Methods Mol Biol 954:251-64
Crimmins, Gregory T; Isberg, Ralph R (2012) Analyzing microbial disease at high resolution: following the fate of the bacterium during infection. Curr Opin Microbiol 15:23-7
Rajagopal, Soumitra; Ji, Yuxin; Xu, Kun et al. (2010) Scaffold proteins IRSp53 and spinophilin regulate localized Rac activation by T-lymphocyte invasion and metastasis protein 1 (TIAM1). J Biol Chem 285:18060-71
Mohammadi, Sina; Isberg, Ralph R (2009) Yersinia pseudotuberculosis virulence determinants invasin, YopE, and YopT modulate RhoG activity and localization. Infect Immun 77:4771-82
Auerbuch, Victoria; Golenbock, Douglas T; Isberg, Ralph R (2009) Innate immune recognition of Yersinia pseudotuberculosis type III secretion. PLoS Pathog 5:e1000686
Heidtman, Matthew; Chen, Emy J; Moy, Man-Yu et al. (2009) Large-scale identification of Legionella pneumophila Dot/Icm substrates that modulate host cell vesicle trafficking pathways. Cell Microbiol 11:230-48
Vance, Russell E; Isberg, Ralph R; Portnoy, Daniel A (2009) Patterns of pathogenesis: discrimination of pathogenic and nonpathogenic microbes by the innate immune system. Cell Host Microbe 6:10-21
Li, Zhiru; Dugan, Aisling S; Bloomfield, Gareth et al. (2009) The amoebal MAP kinase response to Legionella pneumophila is regulated by DupA. Cell Host Microbe 6:253-67
Conover, Gloria M; Martinez-Morales, Fernando; Heidtman, Matthew I et al. (2008) Phosphatidylcholine synthesis is required for optimal function of Legionella pneumophila virulence determinants. Cell Microbiol 10:514-28

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