Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI024780-10
Application #
2062750
Study Section
Allergy and Immunology Study Section (ALY)
Project Start
1986-09-30
Project End
1996-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Chicago
Department
Genetics
Type
Schools of Medicine
DUNS #
225410919
City
Chicago
State
IL
Country
United States
Zip Code
60637
Wang, Z; Engler, P; Longacre, A et al. (2001) An efficient method for high-fidelity BAC/PAC retrofitting with a selectable marker for mammalian cell transfection. Genome Res 11:137-42
Sun, T; Ezekiel, U R; Erskine, L et al. (1999) Signal joint formation is inhibited in murine scid preB cells and fibroblasts in substrates with homopolymeric coding ends. Mol Immunol 36:551-8
Engler, P; Storb, U (1999) Hypomethylation is necessary but not sufficient for V(D)J recombination within a transgenic substrate. Mol Immunol 36:1169-73
Engler, P; Doglio, L T; Bozek, G et al. (1998) A cis-acting element that directs the activity of the murine methylation modifier locus Ssm1. Proc Natl Acad Sci U S A 95:10763-8
Fuller, K; Storb, U (1997) Identification and characterization of the murine Rag1 promoter. Mol Immunol 34:939-54
Ezekiel, U R; Sun, T; Bozek, G et al. (1997) The composition of coding joints formed in V(D)J recombination is strongly affected by the nucleotide sequence of the coding ends and their relationship to the recombination signal sequences. Mol Cell Biol 17:4191-7
Weng, A; Magnuson, T; Storb, U (1995) Strain-specific transgene methylation occurs early in mouse development and can be recapitulated in embryonic stem cells. Development 121:2853-9
Weng, A; Engler, P; Storb, U (1995) The bulk chromatin structure of a murine transgene does not vary with its transcriptional or DNA methylation status. Mol Cell Biol 15:572-9
Storb, U; Roth, P; Kurtz, B K (1994) Gamma 2b transgenic mice as a model for the role of immunoglobulins in B cell development. Immunol Res 13:291-8
Engler, P; Weng, A; Storb, U (1993) Influence of CpG methylation and target spacing on V(D)J recombination in a transgenic substrate. Mol Cell Biol 13:571-7

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