Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI025032-17
Application #
6510377
Study Section
Special Emphasis Panel (NSS)
Program Officer
Voulgaropoulou, Frosso
Project Start
1987-07-01
Project End
2005-04-30
Budget Start
2002-05-01
Budget End
2003-04-30
Support Year
17
Fiscal Year
2002
Total Cost
$495,042
Indirect Cost
Name
Institute for Systems Biology
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98109
Warren, Sarah E; Duong, Hien; Mao, Dat Phat et al. (2011) Generation of a Listeria vaccine strain by enhanced caspase-1 activation. Eur J Immunol 41:1934-40
Miao, Edward A; Mao, Dat P; Yudkovsky, Natalya et al. (2010) Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc Natl Acad Sci U S A 107:3076-80
Warren, Sarah E; Armstrong, Abraham; Hamilton, M Kristina et al. (2010) Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2. J Immunol 185:818-21
Rajan, Jayant V; Warren, Sarah E; Miao, Edward A et al. (2010) Activation of the NLRP3 inflammasome by intracellular poly I:C. FEBS Lett 584:4627-32
Zak, Daniel E; Aderem, Alan (2009) A systems view of host defense. Nat Biotechnol 27:999-1001
Di Paolo, Nelson C; Miao, Edward A; Iwakura, Yoichiro et al. (2009) Virus binding to a plasma membrane receptor triggers interleukin-1 alpha-mediated proinflammatory macrophage response in vivo. Immunity 31:110-21
Bochud, P-Y; Sinsimer, D; Aderem, A et al. (2009) Polymorphisms in Toll-like receptor 4 (TLR4) are associated with protection against leprosy. Eur J Clin Microbiol Infect Dis 28:1055-65
Hertz, Angie L; Bender, Andrew T; Smith, Kimberly C et al. (2009) Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages. Proc Natl Acad Sci U S A 106:21978-83
Miao, Edward A; Ernst, Robert K; Dors, Monica et al. (2008) Pseudomonas aeruginosa activates caspase 1 through Ipaf. Proc Natl Acad Sci U S A 105:2562-7
Warren, Sarah E; Mao, Dat P; Rodriguez, April E et al. (2008) Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. J Immunol 180:7558-64

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