Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37AI028246-16
Application #
6743894
Study Section
Special Emphasis Panel (NSS)
Program Officer
Sharma, Opendra K
Project Start
1999-03-01
Project End
2009-02-28
Budget Start
2004-03-01
Budget End
2005-02-28
Support Year
16
Fiscal Year
2004
Total Cost
$369,963
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Estes, Jacob D; Reilly, Cavan; Trubey, Charles M et al. (2015) Antifibrotic therapy in simian immunodeficiency virus infection preserves CD4+ T-cell populations and improves immune reconstitution with antiretroviral therapy. J Infect Dis 211:744-54
Zeng, Ming; Paiardini, Mirko; Engram, Jessica C et al. (2012) Critical role of CD4 T cells in maintaining lymphoid tissue structure for immune cell homeostasis and reconstitution. Blood 120:1856-67
Zeng, Ming; Haase, Ashley T; Schacker, Timothy W (2012) Lymphoid tissue structure and HIV-1 infection: life or death for T cells. Trends Immunol 33:306-14
Zeng, Ming; Haase, Ashley T (2012) Ex vivo Co-culture of Lymphoid Tissue Stromal Cells and T Cells. Bio Protoc 2:
Zeng, Ming; Southern, Peter J; Reilly, Cavan S et al. (2012) Lymphoid tissue damage in HIV-1 infection depletes naive T cells and limits T cell reconstitution after antiretroviral therapy. PLoS Pathog 8:e1002437
Zeng, Ming; Smith, Anthony J; Wietgrefe, Stephen W et al. (2011) Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections. J Clin Invest 121:998-1008
Schacker, Timothy W; Bosch, Ronald J; Bennett, Kara et al. (2010) Measurement of naive CD4 cells reliably predicts potential for immune reconstitution in HIV. J Acquir Immune Defic Syndr 54:59-62
Estes, Jacob D; Haase, Ashley T; Schacker, Timothy W (2008) The role of collagen deposition in depleting CD4+ T cells and limiting reconstitution in HIV-1 and SIV infections through damage to the secondary lymphoid organ niche. Semin Immunol 20:181-6
Estes, Jacob; Baker, Jason V; Brenchley, Jason M et al. (2008) Collagen deposition limits immune reconstitution in the gut. J Infect Dis 198:456-64
Denton, Paul W; Estes, Jacob D; Sun, Zhifeng et al. (2008) Antiretroviral pre-exposure prophylaxis prevents vaginal transmission of HIV-1 in humanized BLT mice. PLoS Med 5:e16

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