Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37AI033319-08
Application #
2886793
Study Section
Special Emphasis Panel (NSS)
Program Officer
Plaeger, Susan F
Project Start
1992-09-01
Project End
2002-04-30
Budget Start
1999-05-01
Budget End
2000-04-30
Support Year
8
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Shang, Liang; Hunter, Eric (2010) Residues in the membrane-spanning domain core modulate conformation and fusogenicity of the HIV-1 envelope glycoprotein. Virology 404:158-67
Vishwanathan, Sundaram A; Hunter, Eric (2008) Importance of the membrane-perturbing properties of the membrane-proximal external region of human immunodeficiency virus type 1 gp41 to viral fusion. J Virol 82:5118-26
Epand, Raquel F; Thomas, Annick; Brasseur, Robert et al. (2006) Juxtamembrane protein segments that contribute to recruitment of cholesterol into domains. Biochemistry 45:6105-14
Micoli, Keith J; Mamaeva, Olga; Piller, Sabine C et al. (2006) Point mutations in the C-terminus of HIV-1 gp160 reduce apoptosis and calmodulin binding without affecting viral replication. Virology 344:468-79
Lin, Xiaoxu; Derdeyn, Cynthia A; Blumenthal, Robert et al. (2003) Progressive truncations C terminal to the membrane-spanning domain of simian immunodeficiency virus Env reduce fusogenicity and increase concentration dependence of Env for fusion. J Virol 77:7067-77
West, John T; Weldon, Sally K; Wyss, Stephanie et al. (2002) Mutation of the dominant endocytosis motif in human immunodeficiency virus type 1 gp41 can complement matrix mutations without increasing Env incorporation. J Virol 76:3338-49
West, J T; Johnston, P B; Dubay, S R et al. (2001) Mutations within the putative membrane-spanning domain of the simian immunodeficiency virus transmembrane glycoprotein define the minimal requirements for fusion, incorporation, and infectivity. J Virol 75:9601-12
Derdeyn, C A; Decker, J M; Sfakianos, J N et al. (2001) Sensitivity of human immunodeficiency virus type 1 to fusion inhibitors targeted to the gp41 first heptad repeat involves distinct regions of gp41 and is consistently modulated by gp120 interactions with the coreceptor. J Virol 75:8605-14
Piller, S C; Dubay, J W; Derdeyn, C A et al. (2000) Mutational analysis of conserved domains within the cytoplasmic tail of gp41 from human immunodeficiency virus type 1: effects on glycoprotein incorporation and infectivity. J Virol 74:11717-23
Salzwedel, K; West, J T; Hunter, E (1999) A conserved tryptophan-rich motif in the membrane-proximal region of the human immunodeficiency virus type 1 gp41 ectodomain is important for Env-mediated fusion and virus infectivity. J Virol 73:2469-80

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