Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37CA014394-19S1
Application #
3481685
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1991-06-17
Project End
1994-02-28
Budget Start
1991-06-17
Budget End
1992-02-29
Support Year
19
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Type
Schools of Medicine
DUNS #
073133571
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Meyskens Jr, Frank L; Mukhtar, Hasan; Rock, Cheryl L et al. (2016) Cancer Prevention: Obstacles, Challenges and the Road Ahead. J Natl Cancer Inst 108:
Gonzalez-Pacanowska, Dolores; Ruiz-Perez, Luis M; Carreras-Gomez, Maria Angeles et al. (2003) The structural roles of conserved Pro196, Pro197 and His199 in the mechanism of thymidylate synthase. Protein Eng 16:607-14
Kawase, S; Cho, S W; Rozelle, J et al. (2000) Replacement set mutagenesis of the four phosphate-binding arginine residues of thymidylate synthase. Protein Eng 13:557-63
Variath, P; Liu, Y; Lee, T T et al. (2000) Effects of subunit occupancy on partitioning of an intermediate in thymidylate synthase mutants. Biochemistry 39:2429-35
Morse, R J; Kawase, S; Santi, D V et al. (2000) Energetic contributions of four arginines to phosphate-binding in thymidylate synthase are more than additive and depend on optimization of ""effective charge balance"". Biochemistry 39:1011-20
Liu, Y; Barrett, J E; Schultz, P G et al. (1999) Tyrosine 146 of thymidylate synthase assists proton abstraction from the 5-position of 2'-deoxyuridine 5'-monophosphate. Biochemistry 38:848-52
Finer-Moore, J S; Liu, L; Birdsall, D L et al. (1998) Contributions of orientation and hydrogen bonding to catalysis in Asn229 mutants of thymidylate synthase. J Mol Biol 276:113-29
Liu, Y; Santi, D V (1998) A continuous spectrophotometric assay for thymidine and deoxycytidine kinases. Anal Biochem 264:259-62
Huang, L; Pookanjanatavip, M; Gu, X et al. (1998) A conserved aspartate of tRNA pseudouridine synthase is essential for activity and a probable nucleophilic catalyst. Biochemistry 37:344-51
Chiericatti, G; Santi, D V (1998) Aspartate 221 of thymidylate synthase is involved in folate cofactor binding and in catalysis. Biochemistry 37:9038-42

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