Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA018137-21
Application #
2086673
Study Section
Special Emphasis Panel (NSS)
Project Start
1978-12-01
Project End
1996-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Physiology
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033

  Publications

Kotandeniya, Delshanee; Murphy, Daniel; Yan, Shuo et al. (2013) Kinetics of O(6)-pyridyloxobutyl-2'-deoxyguanosine repair by human O(6)-alkylguanine DNA alkyltransferase. Biochemistry 52:4075-88
Tretyakova, Natalia Y; Michaelson-Richie, Erin D; Gherezghiher, Teshome B et al. (2013) DNA-reactive protein monoepoxides induce cell death and mutagenesis in mammalian cells. Biochemistry 52:3171-81
Peterson, Lisa A; Urban, Anna M; Vu, Choua C et al. (2013) Role of aldehydes in the toxic and mutagenic effects of nitrosamines. Chem Res Toxicol 26:1464-73
Kotandeniya, Delshanee; Murphy, Dan; Seneviratne, Uthpala et al. (2011) Mass spectrometry based approach to study the kinetics of O6-alkylguanine DNA alkyltransferase-mediated repair of O6-pyridyloxobutyl-2'-deoxyguanosine adducts in DNA. Chem Res Toxicol 24:1966-75
Kalapila, Aley G; Pegg, Anthony E (2010) Alkyltransferase-mediated toxicity of bis-electrophiles in mammalian cells. Mutat Res 684:35-42
McManus, Francis P; Fang, Qingming; Booth, Jason D M et al. (2010) Synthesis and characterization of an O(6)-2'-deoxyguanosine-alkyl-O(6)-2'-deoxyguanosine interstrand cross-link in a 5'-GNC motif and repair by human O(6)-alkylguanine-DNA alkyltransferase. Org Biomol Chem 8:4414-26
Aramini, James M; Tubbs, Julie L; Kanugula, Sreenivas et al. (2010) Structural basis of O6-alkylguanine recognition by a bacterial alkyltransferase-like DNA repair protein. J Biol Chem 285:13736-41
Guza, Rebecca; Ma, Linan; Fang, Qingming et al. (2009) Cytosine methylation effects on the repair of O6-methylguanines within CG dinucleotides. J Biol Chem 284:22601-10
Li, Li; Perdigao, Joana; Pegg, Anthony E et al. (2009) The influence of repair pathways on the cytotoxicity and mutagenicity induced by the pyridyloxobutylation pathway of tobacco-specific nitrosamines. Chem Res Toxicol 22:1464-72
Tubbs, Julie L; Latypov, Vitaly; Kanugula, Sreenivas et al. (2009) Flipping of alkylated DNA damage bridges base and nucleotide excision repair. Nature 459:808-13

Showing the most recent 10 out of 93 publications