Repair of DNA Damage Induced by Ionizing Radiation

Wallace, Susan S.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Cancer Institute (NCI)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 5R37CA033657-07
• Application #: 3482281
• Study Section: Radiation Study Section (RAD)
• Project Start: 1982-04-01
• Project End: 1988-07-31
• Budget Start: 1988-02-01
• Budget End: 1988-07-31
• Support Year: 7
• Fiscal Year: 1988

Institution

• Name: New York Medical College
• Type: Schools of Medicine
• City: Valhalla
• State: NY
• Country: United States
• Zip Code: 10595

Publications

Wallace, Susan S (2013) DNA glycosylases search for and remove oxidized DNA bases. Environ Mol Mutagen 54:691-704

Faucher, Frédérick; Wallace, Susan S; Doublié, Sylvie (2009) Structural basis for the lack of opposite base specificity of Clostridium acetobutylicum 8-oxoguanine DNA glycosylase. DNA Repair (Amst) 8:1283-9

Yang, Ning; Chaudhry, M Ahmad; Wallace, Susan S (2006) Base excision repair by hNTH1 and hOGG1: a two edged sword in the processing of DNA damage in gamma-irradiated human cells. DNA Repair (Amst) 5:43-51

Bandaru, Viswanath; Blaisdell, Jeffrey O; Wallace, Susan S (2006) Oxidative DNA glycosylases: recipes from cloning to characterization. Methods Enzymol 408:15-33

Watanabe, Takashi; Blaisdell, Jeffrey O; Wallace, Susan S et al. (2005) Engineering functional changes in Escherichia coli endonuclease III based on phylogenetic and structural analyses. J Biol Chem 280:34378-84

Bandaru, Viswanath; Cooper, Wendy; Wallace, Susan S et al. (2004) Overproduction, crystallization and preliminary crystallographic analysis of a novel human DNA-repair enzyme that recognizes oxidative DNA damage. Acta Crystallogr D Biol Crystallogr 60:1142-4

Yang, Ning; Galick, Heather; Wallace, Susan S (2004) Attempted base excision repair of ionizing radiation damage in human lymphoblastoid cells produces lethal and mutagenic double strand breaks. DNA Repair (Amst) 3:1323-34

Doublie, Sylvie; Bandaru, Viswanath; Bond, Jeffrey P et al. (2004) The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity. Proc Natl Acad Sci U S A 101:10284-9

Kathe, Scott D; Shen, Guang-Ping; Wallace, Susan S (2004) Single-stranded breaks in DNA but not oxidative DNA base damages block transcriptional elongation by RNA polymerase II in HeLa cell nuclear extracts. J Biol Chem 279:18511-20

Wallace, Susan S; Bandaru, Viswanath; Kathe, Scott D et al. (2003) The enigma of endonuclease VIII. DNA Repair (Amst) 2:441-53