Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA034992-24
Application #
7021468
Study Section
Special Emphasis Panel (NSS)
Program Officer
Lees, Robert G
Project Start
1983-01-01
Project End
2008-12-31
Budget Start
2006-01-01
Budget End
2006-12-31
Support Year
24
Fiscal Year
2006
Total Cost
$665,354
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
001425594
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Ling, Xiang; Chen, Xing; Riddell, Imogen A et al. (2018) Glutathione-Scavenging Poly(disulfide amide) Nanoparticles for the Effective Delivery of Pt(IV) Prodrugs and Reversal of Cisplatin Resistance. Nano Lett 18:4618-4625
Zhou, Wen; Almeqdadi, Mohammad; Xifaras, Michael E et al. (2018) The effect of geometric isomerism on the anticancer activity of the monofunctional platinum complex trans-[Pt(NH3)2(phenanthridine)Cl]NO3. Chem Commun (Camb) 54:2788-2791
Hucke, Anna; Park, Ga Young; Bauer, Oliver B et al. (2018) Interaction of the New Monofunctional Anticancer Agent Phenanthriplatin With Transporters for Organic Cations. Front Chem 6:180
Awuah, Samuel G; Riddell, Imogen A; Lippard, Stephen J (2017) Repair shielding of platinum-DNA lesions in testicular germ cell tumors by high-mobility group box protein 4 imparts cisplatin hypersensitivity. Proc Natl Acad Sci U S A 114:950-955
Bruno, Peter M; Liu, Yunpeng; Park, Ga Young et al. (2017) A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress. Nat Med 23:461-471
Johnstone, Timothy C; Suntharalingam, Kogularamanan; Lippard, Stephen J (2016) The Next Generation of Platinum Drugs: Targeted Pt(II) Agents, Nanoparticle Delivery, and Pt(IV) Prodrugs. Chem Rev 116:3436-86
Patra, Malay; Johnstone, Timothy C; Suntharalingam, Kogularamanan et al. (2016) A Potent Glucose-Platinum Conjugate Exploits Glucose Transporters and Preferentially Accumulates in Cancer Cells. Angew Chem Int Ed Engl 55:2550-4
Riddell, Imogen A; Agama, Keli; Park, Ga Young et al. (2016) Phenanthriplatin Acts As a Covalent Poison of Topoisomerase II Cleavage Complexes. ACS Chem Biol 11:2996-3001
Czapar, Anna E; Zheng, Yao-Rong; Riddell, Imogen A et al. (2016) Tobacco Mosaic Virus Delivery of Phenanthriplatin for Cancer therapy. ACS Nano 10:4119-26
Zheng, Yao-Rong; Suntharalingam, Kogularamanan; Bruno, Peter M et al. (2016) Mechanistic Studies of the Anticancer Activity of An Octahedral Hexanuclear Pt(II) Cage. Inorganica Chim Acta 452:125-129

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