Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37CA043460-22
Application #
6831635
Study Section
Special Emphasis Panel (NSS)
Program Officer
Okano, Paul
Project Start
1983-08-01
Project End
2006-11-30
Budget Start
2004-12-01
Budget End
2005-11-30
Support Year
22
Fiscal Year
2005
Total Cost
$433,406
Indirect Cost
Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Reiter, Johannes G; Makohon-Moore, Alvin P; Gerold, Jeffrey M et al. (2018) Minimal functional driver gene heterogeneity among untreated metastases. Science 361:1033-1037
Maheshwari, Sweta; Miller, Michelle S; O'Meally, Robert et al. (2017) Kinetic and structural analyses reveal residues in phosphoinositide 3-kinase ? that are critical for catalysis and substrate recognition. J Biol Chem 292:13541-13550
Tomasetti, Cristian; Li, Lu; Vogelstein, Bert (2017) Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention. Science 355:1330-1334
Makohon-Moore, Alvin P; Zhang, Ming; Reiter, Johannes G et al. (2017) Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer. Nat Genet 49:358-366
Le, Dung T; Durham, Jennifer N; Smith, Kellie N et al. (2017) Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade. Science 357:409-413
Masica, David L; Dal Molin, Marco; Wolfgang, Christopher L et al. (2017) A novel approach for selecting combination clinical markers of pathology applied to a large retrospective cohort of surgically resected pancreatic cysts. J Am Med Inform Assoc 24:145-152
Chen, Zan; Jiang, Hanjie; Xu, Wei et al. (2017) A Tunable Brake for HECT Ubiquitin Ligases. Mol Cell 66:345-357.e6
Miller, Michelle S; Maheshwari, Sweta; McRobb, Fiona M et al. (2017) Identification of allosteric binding sites for PI3K? oncogenic mutant specific inhibitor design. Bioorg Med Chem 25:1481-1486
Reiter, Johannes G; Makohon-Moore, Alvin P; Gerold, Jeffrey M et al. (2017) Reconstructing metastatic seeding patterns of human cancers. Nat Commun 8:14114
Hoang, Margaret L; Kinde, Isaac; Tomasetti, Cristian et al. (2016) Genome-wide quantification of rare somatic mutations in normal human tissues using massively parallel sequencing. Proc Natl Acad Sci U S A 113:9846-51

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