Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37DK005736-33S1
Application #
647818
Study Section
Physiology Study Section (PHY)
Project Start
1994-02-01
Project End
1995-01-31
Budget Start
1994-02-01
Budget End
1995-01-31
Support Year
33
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Harvard University
Department
Physiology
Type
Schools of Medicine
DUNS #
082359691
City
Boston
State
MA
Country
United States
Zip Code
02115
Franco, P J; Jena, A B; Wilson, T H (2001) Physiological evidence for an interaction between helices II and XI in the melibiose carrier of Escherichia coli. Biochim Biophys Acta 1510:231-42
Ding, P Z; Wilson, T H (2001) The proximity between helix I and helix XI in the melibiose carrier of Escherichia coli as determined by cross-linking. Biochim Biophys Acta 1514:230-8
Ding, P Z; Wilson, T H (2001) Cysteine mutagenesis of the amino acid residues of transmembrane helix I in the melibiose carrier of Escherichia coli. Biochemistry 40:5506-10
Ding, P Z; Wilson, T H (2001) The effect of modifications of the charged residues in the transmembrane helices on the transport activity of the melibiose carrier of Escherichia coli. Biochem Biophys Res Commun 285:348-54
Ding, P Z; Botfield, M C; Wilson, T H (2000) Sugar recognition mutants of the melibiose carrier of Escherichia coli: possible structural information concerning the arrangement of membrane-bound helices and sugar/cation recognition site. Biochim Biophys Acta 1509:123-30
Varela, M F; Wilson, T H; Rodon-Rivera, V et al. (2000) Mutants of the lactose carrier of Escherichia coli which show altered sugar recognition plus a severe defect in sugar accumulation. J Membr Biol 174:199-205
Ding, P Z; Wilson, T H (2000) Physiological evidence for an interaction between helix XI and helices I, II, and V in the melibiose carrier of Escherichia coli. Biochem Biophys Res Commun 268:409-13
Ding, P Z; Wilson, T H (2000) The melibiose carrier of Escherichia coli: cysteine substitutions for individual residues in helix XI. J Membr Biol 174:135-40
Matsuzaki, S; Weissborn, A C; Tamai, E et al. (1999) Melibiose carrier of Escherichia coli: use of cysteine mutagenesis to identify the amino acids on the hydrophilic face of transmembrane helix 2. Biochim Biophys Acta 1420:63-72
Franco, P J; Wilson, T H (1999) Arg-52 in the melibiose carrier of Escherichia coli is important for cation-coupled sugar transport and participates in an intrahelical salt bridge. J Bacteriol 181:6377-86

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