Biochemical Mechanisms - Enzymes, Cancer, and Models

Bruice, Thomas C.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
• Type: Method to Extend Research in Time (MERIT) Award (R37)
• Project #: 2R37DK009171-26
• Application #: 3482922
• Study Section: Physical Biochemistry Study Section (PB)
• Project Start: 1974-09-01
• Project End: 1994-08-31
• Budget Start: 1989-09-01
• Budget End: 1990-08-31
• Support Year: 26
• Fiscal Year: 1989

Institution

• Name: University of California Santa Barbara
• Type: Schools of Arts and Sciences
• City: Santa Barbara
• State: CA
• Country: United States
• Zip Code: 93106

Publications

Zhang, Xiaodong; Bruice, Thomas C (2008) Mechanism of product specificity of AdoMet methylation catalyzed by lysine methyltransferases: transcriptional factor p53 methylation by histone lysine methyltransferase SET7/9. Biochemistry 47:2743-8

Park, Myunji; Canzio, Daniele; Bruice, Thomas C (2008) Incorporation of positively charged ribonucleic guanidine linkages into oligodeoxyribonucleotides: Development of potent antisense agents. Bioorg Med Chem Lett 18:2377-84

Zhang, Xiaodong; Bruice, Thomas C (2007) Histone lysine methyltransferase SET7/9: formation of a water channel precedes each methyl transfer. Biochemistry 46:14838-44

Zhang, Xiaodong; Reddy, Swarnalatha Y; Bruice, Thomas C (2007) Mechanism of methanol oxidation by quinoprotein methanol dehydrogenase. Proc Natl Acad Sci U S A 104:745-9

Zhang, Xiaodong; Bruice, Thomas C (2007) Catalytic mechanism and product specificity of rubisco large subunit methyltransferase: QM/MM and MD investigations. Biochemistry 46:5505-14

Luo, Jia; Bruice, Thomas C (2007) Low-frequency normal modes in horse liver alcohol dehydrogenase and motions of residues involved in the enzymatic reaction. Biophys Chem 126:80-5

Toporowski, Joseph W; Reddy, Swarnalatha Y; Bruice, Thomas C (2007) An investigation of the ionic and solvation patterns of dsDNG versus dsDNA by use of molecular dynamics simulations. Biophys Chem 126:132-9

Zhang, Xiaodong; Bruice, Thomas C (2007) A quantum mechanics/molecular mechanics study of the catalytic mechanism and product specificity of viral histone lysine methyltransferase. Biochemistry 46:9743-51

Zhang, Xiaodong; Bruice, Thomas C (2006) The mechanism of M.HhaI DNA C5 cytosine methyltransferase enzyme: a quantum mechanics/molecular mechanics approach. Proc Natl Acad Sci U S A 103:6148-53

Correa, Bryan J; Canzio, Daniele; Kahane, Alexandra L et al. (2006) DNA sequence recognition by Hoechst 33258 conjugates of hairpin pyrrole/imidazole polyamides. Bioorg Med Chem Lett 16:3745-50