Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK016746-33
Application #
6879758
Study Section
Special Emphasis Panel (NSS)
Program Officer
Blondel, Olivier
Project Start
1976-04-01
Project End
2008-03-31
Budget Start
2005-04-01
Budget End
2006-03-31
Support Year
33
Fiscal Year
2005
Total Cost
$513,185
Indirect Cost
Name
Washington University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Hara, Takashi; Mahadevan, Jana; Kanekura, Kohsuke et al. (2014) Calcium efflux from the endoplasmic reticulum leads to ?-cell death. Endocrinology 155:758-68
Urano, Fumihiko (2014) Wolfram syndrome iPS cells: the first human cell model of endoplasmic reticulum disease. Diabetes 63:844-6
Kanekura, Kohsuke; Ishigaki, Shinsuke; Merksamer, Philip I et al. (2013) Establishment of a system for monitoring endoplasmic reticulum redox state in mammalian cells. Lab Invest 93:1254-8
Karzon, Roanne K; Hullar, Timothy E (2013) Audiologic and vestibular findings in Wolfram syndrome. Ear Hear 34:809-12
Jung, Dae Young; Chalasani, Umadevi; Pan, Ning et al. (2013) KLF15 is a molecular link between endoplasmic reticulum stress and insulin resistance. PLoS One 8:e77851
Bonnycastle, Lori L; Chines, Peter S; Hara, Takashi et al. (2013) Autosomal dominant diabetes arising from a Wolfram syndrome 1 mutation. Diabetes 62:3943-50
Marshall, Bess A; Permutt, M Alan; Paciorkowski, Alexander R et al. (2013) Phenotypic characteristics of early Wolfram syndrome. Orphanet J Rare Dis 8:64
Oslowski, Christine M; Hara, Takashi; O'Sullivan-Murphy, Bryan et al. (2012) Thioredoxin-interacting protein mediates ER stress-induced ? cell death through initiation of the inflammasome. Cell Metab 16:265-73
Hershey, Tamara; Lugar, Heather M; Shimony, Joshua S et al. (2012) Early brain vulnerability in Wolfram syndrome. PLoS One 7:e40604
Fonseca, Sonya G; Urano, Fumihiko; Weir, Gordon C et al. (2012) Wolfram syndrome 1 and adenylyl cyclase 8 interact at the plasma membrane to regulate insulin production and secretion. Nat Cell Biol 14:1105-12

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