Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37DK017776-29
Application #
6793941
Study Section
Special Emphasis Panel (NSS)
Program Officer
Silva, Corinne M
Project Start
1977-06-01
Project End
2008-12-31
Budget Start
2004-01-01
Budget End
2004-12-31
Support Year
29
Fiscal Year
2004
Total Cost
$623,511
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
073130411
City
Boston
State
MA
Country
United States
Zip Code
02199
Dai, Ning; Ji, Fei; Wright, Jason et al. (2017) IGF2 mRNA binding protein-2 is a tumor promoter that drives cancer proliferation through its client mRNAs IGF2 and HMGA1. Elife 6:
Galan, Jacob A; Avruch, Joseph (2016) MST1/MST2 Protein Kinases: Regulation and Physiologic Roles. Biochemistry 55:5507-5519
Dai, Ning; Zhao, Liping; Wrighting, Diedra et al. (2015) IGF2BP2/IMP2-Deficient mice resist obesity through enhanced translation of Ucp1 mRNA and Other mRNAs encoding mitochondrial proteins. Cell Metab 21:609-21
Papageorgiou, Angela; Rapley, Joseph; Mesirov, Jill P et al. (2015) A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation. PLoS One 10:e0116096
Oshiro, Noriko; Rapley, Joseph; Avruch, Joseph (2014) Amino acids activate mammalian target of rapamycin (mTOR) complex 1 without changing Rag GTPase guanyl nucleotide charging. J Biol Chem 289:2658-74
Regué, Laura; Mou, Fan; Avruch, Joseph (2013) G protein-coupled receptors engage the mammalian Hippo pathway through F-actin: F-Actin, assembled in response to Galpha12/13 induced RhoA-GTP, promotes dephosphorylation and activation of the YAP oncogene. Bioessays 35:430-5
Dai, Ning; Christiansen, Jan; Nielsen, Finn C et al. (2013) mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts. Genes Dev 27:301-12
Wu, Hongtan; Xiao, Yubo; Zhang, Shihao et al. (2013) The Ets transcription factor GABP is a component of the hippo pathway essential for growth and antioxidant defense. Cell Rep 3:1663-77
Avruch, Joseph; Zhou, Dawang; Fitamant, Julien et al. (2012) Protein kinases of the Hippo pathway: regulation and substrates. Semin Cell Dev Biol 23:770-84
Avruch, Joseph; Zhou, Dawang; Bardeesy, Nabeel (2012) YAP oncogene overexpression supercharges colon cancer proliferation. Cell Cycle 11:1090-6

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