Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
2R37DK019971-18
Application #
2137417
Study Section
Pathobiochemistry Study Section (PBC)
Project Start
1977-08-01
Project End
1999-07-31
Budget Start
1994-08-01
Budget End
1995-07-31
Support Year
18
Fiscal Year
1994
Total Cost
Indirect Cost
Name
University of South Carolina at Columbia
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
111310249
City
Columbia
State
SC
Country
United States
Zip Code
29208
Piroli, Gerardo G; Manuel, Allison M; Clapper, Anna C et al. (2016) Succination is Increased on Select Proteins in the Brainstem of the NADH dehydrogenase (ubiquinone) Fe-S protein 4 (Ndufs4) Knockout Mouse, a Model of Leigh Syndrome. Mol Cell Proteomics 15:445-61
Merkley, Eric D; Metz, Thomas O; Smith, Richard D et al. (2014) The succinated proteome. Mass Spectrom Rev 33:98-109
Piroli, Gerardo G; Manuel, Allison M; Walla, Michael D et al. (2014) Identification of protein succination as a novel modification of tubulin. Biochem J 462:231-45
Manuel, Allison M; Frizzell, Norma (2013) Adipocyte protein modification by Krebs cycle intermediates and fumarate ester-derived succination. Amino Acids 45:1243-7
Thomas, Sonia A; Storey, Kenneth B; Baynes, John W et al. (2012) Tissue distribution of S-(2-succino)cysteine (2SC), a biomarker of mitochondrial stress in obesity and diabetes. Obesity (Silver Spring) 20:263-9
Frizzell, Norma; Thomas, Sonia A; Carson, James A et al. (2012) Mitochondrial stress causes increased succination of proteins in adipocytes in response to glucotoxicity. Biochem J 445:247-54
Nagai, Ryoji; Murray, David B; Metz, Thomas O et al. (2012) Chelation: a fundamental mechanism of action of AGE inhibitors, AGE breakers, and other inhibitors of diabetes complications. Diabetes 61:549-59
Frizzell, Norma; Lima, Maria; Baynes, John W (2011) Succination of proteins in diabetes. Free Radic Res 45:101-9
Bardella, Chiara; El-Bahrawy, Mona; Frizzell, Norma et al. (2011) Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status. J Pathol 225:4-11
Nagai, Ryoji; Nagai, Mime; Shimasaki, Satoko et al. (2010) Citric acid inhibits development of cataracts, proteinuria and ketosis in streptozotocin (type 1) diabetic rats. Biochem Biophys Res Commun 393:118-22

Showing the most recent 10 out of 122 publications