Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37DK020251-14S1
Application #
3483333
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1977-08-01
Project End
1992-07-31
Budget Start
1990-08-01
Budget End
1991-07-31
Support Year
14
Fiscal Year
1990
Total Cost
Indirect Cost
Name
North Carolina State University Raleigh
Department
Type
Schools of Earth Sciences/Natur
DUNS #
City
Raleigh
State
NC
Country
United States
Zip Code
27695
Behera, Rabindra K; Theil, Elizabeth C (2014) Moving Fe2+ from ferritin ion channels to catalytic OH centers depends on conserved protein cage carboxylates. Proc Natl Acad Sci U S A 111:7925-30
Kwak, Yeonju; Schwartz, Jennifer K; Haldar, Suranjana et al. (2014) Spectroscopic studies of single and double variants of M ferritin: lack of conversion of a biferrous substrate site into a cofactor site for O2 activation. Biochemistry 53:473-82
Theil, Elizabeth C; Turano, Paola; Ghini, Veronica et al. (2014) Coordinating subdomains of ferritin protein cages with catalysis and biomineralization viewed from the C4 cage axes. J Biol Inorg Chem 19:615-22
Khan, Mateen A; Ma, Jia; Walden, William E et al. (2014) Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions. Nucleic Acids Res 42:6567-77
Tosha, Takehiko; Behera, Rabindra K; Theil, Elizabeth C (2012) Ferritin ion channel disorder inhibits Fe(II)/O2 reactivity at distant sites. Inorg Chem 51:11406-11
Bertini, Ivano; Lalli, Daniela; Mangani, Stefano et al. (2012) Structural insights into the ferroxidase site of ferritins from higher eukaryotes. J Am Chem Soc 134:6169-76
Theil, Elizabeth C; Chen, Huijun; Miranda, Constanza et al. (2012) Absorption of iron from ferritin is independent of heme iron and ferrous salts in women and rat intestinal segments. J Nutr 142:478-83
Tosha, Takehiko; Behera, Rabindra K; Ng, Ho-Leung et al. (2012) Ferritin protein nanocage ion channels: gating by N-terminal extensions. J Biol Chem 287:13016-25
Ma, Jia; Haldar, Suranjana; Khan, Mateen A et al. (2012) Fe2+ binds iron responsive element-RNA, selectively changing protein-binding affinities and regulating mRNA repression and activation. Proc Natl Acad Sci U S A 109:8417-22
Theil, Elizabeth C (2011) Iron homeostasis and nutritional iron deficiency. J Nutr 141:724S-728S

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