Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK027083-18
Application #
2137960
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1980-04-01
Project End
1997-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Pathology
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Solé-Domènech, Santiago; Rojas, Ana V; Maisuradze, Gia G et al. (2018) Lysosomal enzyme tripeptidyl peptidase 1 destabilizes fibrillar A? by multiple endoproteolytic cleavages within the ?-sheet domain. Proc Natl Acad Sci U S A 115:1493-1498
Pipalia, Nina H; Subramanian, Kanagaraj; Mao, Shu et al. (2017) Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells. J Lipid Res 58:695-708
Iaea, David B; Maxfield, Frederick R (2017) Membrane order in the plasma membrane and endocytic recycling compartment. PLoS One 12:e0188041
Coats, Brittney R; Schoenfelt, Kelly Q; Barbosa-Lorenzi, Valéria C et al. (2017) Metabolically Activated Adipose Tissue Macrophages Perform Detrimental and Beneficial Functions during Diet-Induced Obesity. Cell Rep 20:3149-3161
Singh, Rajesh K; Haka, Abigail S; Brumfield, Alexandria et al. (2017) Ceramide activation of RhoA/Rho kinase impairs actin polymerization during aggregated LDL catabolism. J Lipid Res 58:1977-1987
Iaea, David B; Mao, Shu; Lund, Frederik W et al. (2017) Role of STARD4 in sterol transport between the endocytic recycling compartment and the plasma membrane. Mol Biol Cell 28:1111-1122
Solé-Domènech, Santiago; Cruz, Dana L; Capetillo-Zarate, Estibaliz et al. (2016) The endocytic pathway in microglia during health, aging and Alzheimer's disease. Ageing Res Rev 32:89-103
Haka, Abigail S; Barbosa-Lorenzi, Valéria C; Lee, Hyuek Jong et al. (2016) Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation. J Lipid Res 57:980-92
Singh, Rajesh K; Barbosa-Lorenzi, Valéria C; Lund, Frederik W et al. (2016) Degradation of aggregated LDL occurs in complex extracellular sub-compartments of the lysosomal synapse. J Cell Sci 129:1072-82
Iaea, David B; Maxfield, Frederick R (2015) Cholesterol trafficking and distribution. Essays Biochem 57:43-55

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