Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK027221-18
Application #
2016040
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1979-11-01
Project End
1997-07-31
Budget Start
1996-09-19
Budget End
1997-07-31
Support Year
18
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Indiana University-Purdue University at Indianapolis
Department
Biochemistry
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Irimia, Jose M; Meyer, Catalina M; Segvich, Dyann M et al. (2017) Lack of liver glycogen causes hepatic insulin resistance and steatosis in mice. J Biol Chem 292:10455-10464
Mahalingan, Krishna K; Baskaran, Sulochanadevi; DePaoli-Roach, Anna A et al. (2017) Redox Switch for the Inhibited State of Yeast Glycogen Synthase Mimics Regulation by Phosphorylation. Biochemistry 56:179-188
Contreras, Christopher J; Segvich, Dyann M; Mahalingan, Krishna et al. (2016) Incorporation of phosphate into glycogen by glycogen synthase. Arch Biochem Biophys 597:21-9
Ruchti, E; Roach, P J; DePaoli-Roach, A A et al. (2016) Protein targeting to glycogen is a master regulator of glycogen synthesis in astrocytes. IBRO Rep 1:46-53
DePaoli-Roach, Anna A; Contreras, Christopher J; Segvich, Dyann M et al. (2015) Glycogen phosphomonoester distribution in mouse models of the progressive myoclonic epilepsy, Lafora disease. J Biol Chem 290:841-50
Roach, Peter J (2015) Glycogen phosphorylation and Lafora disease. Mol Aspects Med 46:78-84
Irimia, Jose M; Tagliabracci, Vincent S; Meyer, Catalina M et al. (2015) Muscle glycogen remodeling and glycogen phosphate metabolism following exhaustive exercise of wild type and laforin knockout mice. J Biol Chem 290:22686-98
Garyali, Punitee; Segvich, Dyann M; DePaoli-Roach, Anna A et al. (2014) Protein degradation and quality control in cells from laforin and malin knockout mice. J Biol Chem 289:20606-14
Coate, Katie C; Kraft, Guillaume; Moore, Mary Courtney et al. (2014) Hepatic glucose uptake and disposition during short-term high-fat vs. high-fructose feeding. Am J Physiol Endocrinol Metab 307:E151-60
Ruiz, Rafaela; Jideonwo, Victoria; Ahn, Miwon et al. (2014) Sterol regulatory element-binding protein-1 (SREBP-1) is required to regulate glycogen synthesis and gluconeogenic gene expression in mouse liver. J Biol Chem 289:5510-7

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