Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK031036-36
Application #
9320657
Study Section
Special Emphasis Panel (NSS)
Program Officer
Silva, Corinne M
Project Start
2015-04-01
Project End
2020-03-31
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
36
Fiscal Year
2017
Total Cost
$555,570
Indirect Cost
$219,878

  Institution

Name
Joslin Diabetes Center
Department
Type
Research Institutes
DUNS #
071723084
City
Boston
State
MA
Country
United States
Zip Code
02215

  Publications

Viana-Huete, Vanesa; Guillén, Carlos; García, Gema et al. (2018) Male Brown Fat-Specific Double Knockout of IGFIR/IR: Atrophy, Mitochondrial Fission Failure, Impaired Thermogenesis, and Obesity. Endocrinology 159:323-340
Garcia-Castillo, Maria Daniela; Chinnapen, Daniel J-F; Te Welscher, Yvonne M et al. (2018) Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids. Elife 7:
Sajan, Mini P; Hansen, Barbara C; Higgs, Margaret G et al. (2018) Atypical PKC, PKC?/?, activates ?-secretase and increases A?1-40/42 and phospho-tau in mouse brain and isolated neuronal cells, and may link hyperinsulinemia and other aPKC activators to development of pathological and memory abnormalities in Alzheimer's Neurobiol Aging 61:225-237
Soto, Marion; Orliaguet, Lucie; Reyzer, Michelle L et al. (2018) Pyruvate induces torpor in obese mice. Proc Natl Acad Sci U S A 115:810-815
Ussar, Siegfried; Haering, Max-Felix; Fujisaka, Shiho et al. (2017) Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor. Diabetes 66:886-896
Kahn, C Ronald; Ussar, Siegfried (2017) Response to Comment on Ussar et al. Regulation of Glucose Uptake and Enteroendocrine Function by the Intestinal Epithelial Insulin Receptor. Diabetes 2017;66:886-896. Diabetes 66:e6
Konishi, Masahiro; Sakaguchi, Masaji; Lockhart, Samuel M et al. (2017) Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice. Proc Natl Acad Sci U S A 114:E8478-E8487
Wang, X; Häring, M-F; Rathjen, T et al. (2017) Insulin resistance in vascular endothelial cells promotes intestinal tumour formation. Oncogene 36:4987-4996
Ferris, Heather A; Perry, Rachel J; Moreira, Gabriela V et al. (2017) Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism. Proc Natl Acad Sci U S A 114:1189-1194
Cai, Weikang; Sakaguchi, Masaji; Kleinridders, Andre et al. (2017) Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nat Commun 8:14892

Showing the most recent 10 out of 137 publications