Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37DK034388-12
Application #
2139293
Study Section
Metabolism Study Section (MET)
Project Start
1984-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
12
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Washington University
Department
Pathology
Type
Schools of Medicine
DUNS #
062761671
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Turk, John; White, Tayleur D; Nelson, Alexander J et al. (2018) iPLA2? and its role in male fertility, neurological disorders, metabolic disorders, and inflammation. Biochim Biophys Acta Mol Cell Biol Lipids :
Thimgan, Matthew S; Seugnet, Laurent; Turk, John et al. (2015) Identification of genes associated with resilience/vulnerability to sleep deprivation and starvation in Drosophila. Sleep 38:801-14
Tan, Chunyan; Day, Robert; Bao, Shunzhong et al. (2014) Group VIA phospholipase A2 mediates enhanced macrophage migration in diabetes mellitus by increasing expression of nicotinamide adenine dinucleotide phosphate oxidase 4. Arterioscler Thromb Vasc Biol 34:768-78
Blanchard, Helene; Taha, Ameer Y; Cheon, Yewon et al. (2014) iPLA2? knockout mouse, a genetic model for progressive human motor disorders, develops age-related neuropathology. Neurochem Res 39:1522-32
Lei, Xiaoyong; Bone, Robert N; Ali, Tomader et al. (2014) Evidence of contribution of iPLA2?-mediated events during islet ?-cell apoptosis due to proinflammatory cytokines suggests a role for iPLA2? in T1D development. Endocrinology 155:3352-64
Song, Haowei; Wohltmann, Mary; Tan, Min et al. (2014) Group VIA phospholipase A2 mitigates palmitate-induced ?-cell mitochondrial injury and apoptosis. J Biol Chem 289:14194-210
Lei, Xiaoyong; Bone, Robert N; Ali, Tomader et al. (2013) Genetic modulation of islet ?-cell iPLA?? expression provides evidence for its impact on ?-cell apoptosis and autophagy. Islets 5:29-44
Tatituri, Raju V V; Watts, Gerald F M; Bhowruth, Veemal et al. (2013) Recognition of microbial and mammalian phospholipid antigens by NKT cells with diverse TCRs. Proc Natl Acad Sci U S A 110:1827-32
Sharma, Janhavi; Young, Dawn M; Marentette, John O et al. (2012) Lung endothelial cell platelet-activating factor production and inflammatory cell adherence are increased in response to cigarette smoke component exposure. Am J Physiol Lung Cell Mol Physiol 302:L47-55
Bao, Shunzhong; Song, Haowei; Tan, Min et al. (2012) Group VIB Phospholipase A(2) promotes proliferation of INS-1 insulinoma cells and attenuates lipid peroxidation and apoptosis induced by inflammatory cytokines and oxidant agents. Oxid Med Cell Longev 2012:989372

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