Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM019301-30
Application #
6385028
Study Section
Special Emphasis Panel (NSS)
Program Officer
Flicker, Paula F
Project Start
1978-05-01
Project End
2005-04-30
Budget Start
2001-05-01
Budget End
2002-04-30
Support Year
30
Fiscal Year
2001
Total Cost
$387,891
Indirect Cost
Name
University of California San Diego
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Hu, Jiancheng; Ahuja, Lalima G; Meharena, Hiruy S et al. (2015) Kinase regulation by hydrophobic spine assembly in cancer. Mol Cell Biol 35:264-76
Niyitegeka, Jean-Marie V; Bastidas, Adam C; Newman, Robert H et al. (2015) Isoform-specific interactions between meprin metalloproteases and the catalytic subunit of protein kinase A: significance in acute and chronic kidney injury. Am J Physiol Renal Physiol 308:F56-68
Knape, Matthias J; Ahuja, Lalima G; Bertinetti, Daniela et al. (2015) Divalent Metal Ions Mg²? and Ca²? Have Distinct Effects on Protein Kinase A Activity and Regulation. ACS Chem Biol 10:2303-15
Kornev, Alexandr P; Taylor, Susan S (2015) Dynamics-Driven Allostery in Protein Kinases. Trends Biochem Sci 40:628-647
Taylor, Susan S; Shaw, Andrey S; Kannan, Natarajan et al. (2015) Integration of signaling in the kinome: Architecture and regulation of the ?C Helix. Biochim Biophys Acta 1854:1567-74
Bastidas, Adam C; Wu, Jian; Taylor, Susan S (2015) Molecular features of product release for the PKA catalytic cycle. Biochemistry 54:2-10
Gerlits, Oksana; Waltman, Mary Jo; Taylor, Susan et al. (2013) Insights into the phosphoryl transfer catalyzed by cAMP-dependent protein kinase: an X-ray crystallographic study of complexes with various metals and peptide substrate SP20. Biochemistry 52:3721-7
Bastidas, Adam C; Deal, Michael S; Steichen, Jon M et al. (2013) Phosphoryl transfer by protein kinase A is captured in a crystal lattice. J Am Chem Soc 135:4788-98
Taylor, Susan S; Zhang, Ping; Steichen, Jon M et al. (2013) PKA: lessons learned after twenty years. Biochim Biophys Acta 1834:1271-8
Hu, Jiancheng; Stites, Edward C; Yu, Haiyang et al. (2013) Allosteric activation of functionally asymmetric RAF kinase dimers. Cell 154:1036-1046

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