Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM020877-21
Application #
2173625
Study Section
Metallobiochemistry Study Section (BMT)
Project Start
1978-09-01
Project End
1996-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Biochemistry
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Spolitak, Tatyana; Ballou, David P (2015) Evidence for catalytic intermediates involved in generating the chromopyrrolic acid scaffold of rebeccamycin by RebO and RebD. Arch Biochem Biophys 573:111-9
Singh, Sangita; Ballou, David P; Banerjee, Ruma (2011) Pre-steady-state kinetic analysis of enzyme-monitored turnover during cystathionine ?-synthase-catalyzed H(2)S generation. Biochemistry 50:419-25
Galinato, Mary Grace I; Spolitak, Tatyana; Ballou, David P et al. (2011) Elucidating the role of the proximal cysteine hydrogen-bonding network in ferric cytochrome P450cam and corresponding mutants using magnetic circular dichroism spectroscopy. Biochemistry 50:1053-69
Spolitak, Tatyana; Funhoff, Enrico G; Ballou, David P (2010) Spectroscopic studies of the oxidation of ferric CYP153A6 by peracids: Insights into P450 higher oxidation states. Arch Biochem Biophys 493:184-91
Mayfield, Jeffery A; Frederick, Rosanne E; Streit, Bennett R et al. (2010) Comprehensive spectroscopic, steady state, and transient kinetic studies of a representative siderophore-associated flavin monooxygenase. J Biol Chem 285:30375-88
Tarasev, Michael; Pullela, Sailaja; Ballou, David P (2009) Distal end of 105-125 loop--a putative reductase binding domain of phthalate dioxygenase. Arch Biochem Biophys 487:10-8
Lee, Moon N; Takawira, Desire; Nikolova, Andriana P et al. (2009) Functional role for the conformationally mobile phenylalanine 223 in the reaction of methylenetetrahydrofolate reductase from Escherichia coli. Biochemistry 48:7673-85
Shebley, Mohamad; Kent, Ute M; Ballou, David P et al. (2009) Mechanistic analysis of the inactivation of cytochrome P450 2B6 by phencyclidine: effects on substrate binding, electron transfer, and uncoupling. Drug Metab Dispos 37:745-52
Tarasev, Michael; Kaddis, Catherine S; Yin, Sheng et al. (2007) Similar enzymes, different structures: phthalate dioxygenase is an alpha3alpha3 stacked hexamer, not an alpha3beta3 trimer like ""normal"" Rieske oxygenases. Arch Biochem Biophys 466:31-9