Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM023377-21
Application #
2174079
Study Section
Special Emphasis Panel (NSS)
Project Start
1976-05-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
21
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Dartmouth College
Department
Biochemistry
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Orr, Amy; Wickner, William; Rusin, Scott F et al. (2015) Yeast vacuolar HOPS, regulated by its kinase, exploits affinities for acidic lipids and Rab:GTP for membrane binding and to catalyze tethering and fusion. Mol Biol Cell 26:305-15
Baker, Richard W; Jeffrey, Philip D; Zick, Michael et al. (2015) A direct role for the Sec1/Munc18-family protein Vps33 as a template for SNARE assembly. Science 349:1111-4
Xu, Hao; Wickner, William T (2012) N-terminal domain of vacuolar SNARE Vam7p promotes trans-SNARE complex assembly. Proc Natl Acad Sci U S A 109:17936-41
Xu, Hao; Zick, Michael; Wickner, William T et al. (2011) A lipid-anchored SNARE supports membrane fusion. Proc Natl Acad Sci U S A 108:17325-30
Zucchi, Paola C; Zick, Michael (2011) Membrane fusion catalyzed by a Rab, SNAREs, and SNARE chaperones is accompanied by enhanced permeability to small molecules and by lysis. Mol Biol Cell 22:4635-46
Xu, Hao; Wickner, William (2010) Phosphoinositides function asymmetrically for membrane fusion, promoting tethering and 3Q-SNARE subcomplex assembly. J Biol Chem 285:39359-65
Xu, Hao; Jun, Youngsoo; Thompson, James et al. (2010) HOPS prevents the disassembly of trans-SNARE complexes by Sec17p/Sec18p during membrane fusion. EMBO J 29:1948-60
Mima, Joji; Wickner, William (2009) Phosphoinositides and SNARE chaperones synergistically assemble and remodel SNARE complexes for membrane fusion. Proc Natl Acad Sci U S A 106:16191-6
Stroupe, Christopher; Hickey, Christopher M; Mima, Joji et al. (2009) Minimal membrane docking requirements revealed by reconstitution of Rab GTPase-dependent membrane fusion from purified components. Proc Natl Acad Sci U S A 106:17626-33
Mima, Joji; Hickey, Christopher M; Xu, Hao et al. (2008) Reconstituted membrane fusion requires regulatory lipids, SNAREs and synergistic SNARE chaperones. EMBO J 27:2031-42

Showing the most recent 10 out of 22 publications