Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37GM028039-11S1
Application #
3484624
Study Section
Molecular Biology Study Section (MBY)
Project Start
1980-08-01
Project End
1993-07-31
Budget Start
1991-06-01
Budget End
1991-07-31
Support Year
11
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Colorado at Boulder
Department
Type
Schools of Arts and Sciences
DUNS #
City
Boulder
State
CO
Country
United States
Zip Code
80309
Nandakumar, Jayakrishnan; Cech, Thomas R (2012) DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe. Nucleic Acids Res 40:235-44
Zappulla, David C; Goodrich, Karen J; Arthur, Julian R et al. (2011) Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP. RNA 17:298-311
Taylor, Derek J; Podell, Elaine R; Taatjes, Dylan J et al. (2011) Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA. J Mol Biol 410:10-7
Latrick, Chrysa M; Cech, Thomas R (2010) POT1-TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation. EMBO J 29:924-33
Zappulla, David C; Roberts, Jennifer N; Goodrich, Karen J et al. (2009) Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p. Nucleic Acids Res 37:354-67
Subramanian, Lakxmi; Moser, Bettina A; Nakamura, Toru M (2008) Recombination-based telomere maintenance is dependent on Tel1-MRN and Rap1 and inhibited by telomerase, Taz1, and Ku in fission yeast. Mol Cell Biol 28:1443-55
Mandell, Jeffrey G; Goodrich, Karen J; Bahler, Jurg et al. (2005) Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase. J Biol Chem 280:5249-57
Zappulla, David C; Goodrich, Karen; Cech, Thomas R (2005) A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro. Nat Struct Mol Biol 12:1072-7
Zappulla, David C; Cech, Thomas R (2004) Yeast telomerase RNA: a flexible scaffold for protein subunits. Proc Natl Acad Sci U S A 101:10024-9
Aigner, Stefan; Cech, Thomas R (2004) The Euplotes telomerase subunit p43 stimulates enzymatic activity and processivity in vitro. RNA 10:1108-18

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