Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37GM029513-16
Application #
2175554
Study Section
Molecular Cytology Study Section (CTY)
Project Start
1981-07-01
Project End
1999-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Levine, Michelle S; Bakker, Bjorn; Boeckx, Bram et al. (2017) Centrosome Amplification Is Sufficient to Promote Spontaneous Tumorigenesis in Mammals. Dev Cell 40:313-322.e5
Ly, Peter; Teitz, Levi S; Kim, Dong H et al. (2017) Selective Y centromere inactivation triggers chromosome shattering in micronuclei and repair by non-homologous end joining. Nat Cell Biol 19:68-75
Holland, Andrew J; Reis, Rita M; Niessen, Sherry et al. (2015) Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors. Mol Biol Cell 26:1845-56
Vitre, Benjamin; Holland, Andrew J; Kulukian, Anita et al. (2015) Chronic centrosome amplification without tumorigenesis. Proc Natl Acad Sci U S A 112:E6321-30
Holland, Andrew J; Fachinetti, Daniele; Han, Joo Seok et al. (2012) Inducible, reversible system for the rapid and complete degradation of proteins in mammalian cells. Proc Natl Acad Sci U S A 109:E3350-7
Holland, Andrew J; Cleveland, Don W (2012) Losing balance: the origin and impact of aneuploidy in cancer. EMBO Rep 13:501-14
Holland, Andrew J; Cleveland, Don W (2012) The deubiquitinase USP44 is a tumor suppressor that protects against chromosome missegregation. J Clin Invest 122:4325-8
Holland, Andrew J; Fachinetti, Daniele; Da Cruz, Sandrine et al. (2012) Polo-like kinase 4 controls centriole duplication but does not directly regulate cytokinesis. Mol Biol Cell 23:1838-45
Holland, Andrew J; Fachinetti, Daniele; Zhu, Quan et al. (2012) The autoregulated instability of Polo-like kinase 4 limits centrosome duplication to once per cell cycle. Genes Dev 26:2684-9
Holland, Andrew J; Cleveland, Don W (2012) Chromoanagenesis and cancer: mechanisms and consequences of localized, complex chromosomal rearrangements. Nat Med 18:1630-8

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