Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM030324-26
Application #
6821111
Study Section
Special Emphasis Panel (NSS)
Program Officer
Anderson, Richard A
Project Start
1988-09-01
Project End
2008-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
26
Fiscal Year
2004
Total Cost
$416,115
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Pharmacology
Type
Schools of Medicine
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Zawistowski, Jon S; Nakamura, Kazuhiro; Parker, Joel S et al. (2013) MicroRNA 9-3p targets ?1 integrin to sensitize claudin-low breast cancer cells to MEK inhibition. Mol Cell Biol 33:2260-74
Duncan, James S; Whittle, Martin C; Nakamura, Kazuhiro et al. (2012) Dynamic reprogramming of the kinome in response to targeted MEK inhibition in triple-negative breast cancer. Cell 149:307-21
Cronan, M R; Nakamura, K; Johnson, N L et al. (2012) Defining MAP3 kinases required for MDA-MB-231 cell tumor growth and metastasis. Oncogene 31:3889-900
Jordan, Nicole Vincent; Johnson, Gary L; Abell, Amy N (2011) Tracking the intermediate stages of epithelial-mesenchymal transition in epithelial stem cells and cancer. Cell Cycle 10:2865-73
Huang, Weichun; Umbach, David M; Vincent Jordan, Nicole et al. (2011) Efficiently identifying genome-wide changes with next-generation sequencing data. Nucleic Acids Res 39:e130
Abell, Amy N; Jordan, Nicole Vincent; Huang, Weichun et al. (2011) MAP3K4/CBP-regulated H2B acetylation controls epithelial-mesenchymal transition in trophoblast stem cells. Cell Stem Cell 8:525-37
Nakamura, Kazuhiro; Kimple, Adam J; Siderovski, David P et al. (2010) PB1 domain interaction of p62/sequestosome 1 and MEKK3 regulates NF-kappaB activation. J Biol Chem 285:2077-89
Konhilas, John P; Boucek, Dana M; Horn, Todd R et al. (2010) The role of MEKK1 in hypertrophic cardiomyopathy. Int Heart J 51:277-84
Nakamura, Kazuhiro; Johnson, Gary L (2010) Activity assays for extracellular signal-regulated kinase 5. Methods Mol Biol 661:91-106
Abell, Amy N; Granger, Deborah A; Johnson, Nancy L et al. (2009) Trophoblast stem cell maintenance by fibroblast growth factor 4 requires MEKK4 activation of Jun N-terminal kinase. Mol Cell Biol 29:2748-61

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