Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37GM032134-14S1
Application #
1048173
Study Section
Special Emphasis Panel (NSS)
Project Start
1983-01-01
Project End
1998-08-31
Budget Start
1995-09-01
Budget End
1996-08-31
Support Year
14
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts Institute of Technology
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
City
Cambridge
State
MA
Country
United States
Zip Code
02139
Wang, Weixue; Liang, Alexandria D; Lippard, Stephen J (2015) Coupling Oxygen Consumption with Hydrocarbon Oxidation in Bacterial Multicomponent Monooxygenases. Acc Chem Res 48:2632-9
Liang, Alexandria Deliz; Lippard, Stephen J (2015) Single Turnover Reveals Oxygenated Intermediates in Toluene/o-Xylene Monooxygenase in the Presence of the Native Redox Partners. J Am Chem Soc 137:10520-3
Sazinsky, Matthew H; Lippard, Stephen J (2015) Methane monooxygenase: functionalizing methane at iron and copper. Met Ions Life Sci 15:205-56
Majumdar, Amit; Apfel, Ulf-Peter; Jiang, Yunbo et al. (2014) Versatile reactivity of a solvent-coordinated diiron(II) compound: synthesis and dioxygen reactivity of a mixed-valent Fe(II)Fe(III) species. Inorg Chem 53:167-81
Jiang, Yunbo; Hayashi, Takahiro; Matsumura, Hirotoshi et al. (2014) Light-induced N?O production from a non-heme iron-nitrosyl dimer. J Am Chem Soc 136:12524-7
Wang, Weixue; Iacob, Roxana E; Luoh, Rebecca P et al. (2014) Electron transfer control in soluble methane monooxygenase. J Am Chem Soc 136:9754-62
Wang, Weixue; Lippard, Stephen J (2014) Diiron oxidation state control of substrate access to the active site of soluble methane monooxygenase mediated by the regulatory component. J Am Chem Soc 136:2244-7
Lu, Tsai-Te; Lee, Seung Jae; Apfel, Ulf-Peter et al. (2013) Aging-associated enzyme human clock-1: substrate-mediated reduction of the diiron center for 5-demethoxyubiquinone hydroxylation. Biochemistry 52:2236-44
Do, Loi H; Xue, Genqiang; Que Jr, Lawrence et al. (2012) Evaluating the identity and diiron core transformations of a (ýý-oxo)diiron(III) complex supported by electron-rich tris(pyridyl-2-methyl)amine ligands. Inorg Chem 51:2393-402
Li, Yang; Wilson, Justin J; Do, Loi H et al. (2012) A C2-symmetric, basic Fe(III) carboxylate complex derived from a novel triptycene-based chelating carboxylate ligand. Dalton Trans 41:9272-5

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