Abstract

Principal Investigator/Program Director (Last, First, Middle): Silver, Pamela A. BUDGET JUSTIFICATION PAGE MODULAR RESEARCH GRANT APPLICATION Sum Total Initial Period -nd 3rd 4th 5th (For Entire Project Period) DC less Consortium F&A 250,000 250,000 250,000 250,000 250,000 1,250,000 (Item 7a, Face Page) (Item 8a, FacePage) Consortium F&A 0 0 0 0 o 0 Total Direct Costs 250,000 25,000 250,000 250,000 250,000 1 $ 1 ,250,000 |

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM036373-24
Application #
7319896
Study Section
Special Emphasis Panel (NSS)
Program Officer
Shapiro, Bert I
Project Start
1993-06-01
Project End
2013-03-31
Budget Start
2008-04-01
Budget End
2009-03-31
Support Year
24
Fiscal Year
2008
Total Cost
$422,500
Indirect Cost

  Institution

Name
Harvard University
Department
Biology
Type
Schools of Medicine
DUNS #
047006379
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Wang, Qingqing; Moore, Michael J; Adelmant, Guillaume et al. (2013) PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth. Genes Dev 27:615-26
Adelmant, Guillaume; Calkins, Anne S; Garg, Brijesh K et al. (2012) DNA ends alter the molecular composition and localization of Ku multicomponent complexes. Mol Cell Proteomics 11:411-21
Lohmueller, Jason J; Armel, Thomas Z; Silver, Pamela A (2012) A tunable zinc finger-based framework for Boolean logic computation in mammalian cells. Nucleic Acids Res 40:5180-7
Haynes, Karmella A; Ceroni, Francesca; Flicker, Daniel et al. (2012) A sensitive switch for visualizing natural gene silencing in single cells. ACS Synth Biol 1:99-106
Boyle, Patrick M; Silver, Pamela A (2012) Parts plus pipes: synthetic biology approaches to metabolic engineering. Metab Eng 14:223-32
Smolke, Christina D; Silver, Pamela A (2011) Informing biological design by integration of systems and synthetic biology. Cell 144:855-9
Haynes, Karmella A; Silver, Pamela A (2011) Synthetic reversal of epigenetic silencing. J Biol Chem 286:27176-82
Senapedis, William T; Kennedy, Caleb J; Boyle, Patrick M et al. (2011) Whole genome siRNA cell-based screen links mitochondria to Akt signaling network through uncoupling of electron transport chain. Mol Biol Cell 22:1791-805
Burrill, Devin R; Silver, Pamela A (2011) Recording cellular experiences of DNA damage. Cell Cycle 10:2410-1
Burrill, Devin R; Silver, Pamela A (2011) Synthetic circuit identifies subpopulations with sustained memory of DNA damage. Genes Dev 25:434-9

Showing the most recent 10 out of 32 publications