Abstract

Our lab has been focused on how cells sense and respond to DNA damage. We have been very active n elucidating the structures sensed by the DNA damage response sensors. Through work in both yeast and mammals we have established an outline of the signal transduction pathway that is activated in response to DNA damage. This pathway consists of a protein kinase cascade. We have been very interested in understanding how the DNA damage response controls various aspects of cell cycle regulation and have therefore studied the cell cycle as well. In order to understand how the DNA damage response accomplishes its goals, it is imperative we identify the substrates of the kinases activated in response to DNA damage and elucidate the function of these substrates.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
4R37GM044664-20
Application #
7382859
Study Section
Special Emphasis Panel (NSS)
Program Officer
Zatz, Marion M
Project Start
1990-07-01
Project End
2013-06-30
Budget Start
2008-07-01
Budget End
2009-06-30
Support Year
20
Fiscal Year
2008
Total Cost
$350,000
Indirect Cost

  Institution

Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115

  Publications

Borkent, Marti; Bennett, Brian D; Lackford, Brad et al. (2016) A Serial shRNA Screen for Roadblocks to Reprogramming Identifies the Protein Modifier SUMO2. Stem Cell Reports 6:704-716
Willis, Nicholas A; Zhou, Chunshui; Elia, Andrew E H et al. (2016) Identification of S-phase DNA damage-response targets in fission yeast reveals conservation of damage-response networks. Proc Natl Acad Sci U S A 113:E3676-85
Kang, Chanhee; Xu, Qikai; Martin, Timothy D et al. (2015) The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4. Science 349:aaa5612
Elia, Andrew E H; Boardman, Alexander P; Wang, David C et al. (2015) Quantitative Proteomic Atlas of Ubiquitination and Acetylation in the DNA Damage Response. Mol Cell 59:867-81
Izhar, Lior; Adamson, Britt; Ciccia, Alberto et al. (2015) A Systematic Analysis of Factors Localized to Damaged Chromatin Reveals PARP-Dependent Recruitment of Transcription Factors. Cell Rep 11:1486-500
Ciccia, Alberto; Huang, Jen-Wei; Izhar, Lior et al. (2014) Treacher Collins syndrome TCOF1 protein cooperates with NBS1 in the DNA damage response. Proc Natl Acad Sci U S A 111:18631-6
Wang, Charlotte I; Alekseyenko, Artyom A; LeRoy, Gary et al. (2013) Chromatin proteins captured by ChIP-mass spectrometry are linked to dosage compensation in Drosophila. Nat Struct Mol Biol 20:202-9
Adamson, Britt; Smogorzewska, Agata; Sigoillot, Frederic D et al. (2012) A genome-wide homologous recombination screen identifies the RNA-binding protein RBMX as a component of the DNA-damage response. Nat Cell Biol 14:318-28
Zhu, Jian; Gaiha, Gaurav D; John, Sinu P et al. (2012) Reactivation of latent HIV-1 by inhibition of BRD4. Cell Rep 2:807-16
Elia, Andrew E H; Elledge, Stephen J (2012) BRCA1 as tumor suppressor: lord without its RING? Breast Cancer Res 14:306

Showing the most recent 10 out of 76 publications