Project Start
1977-09-30
Project End
1997-06-30
Budget Start
1997-04-01
Budget End
1997-06-30
Support Year
19
Fiscal Year
1997
Total Cost
Indirect Cost
City
Torrance
State
CA
Country
United States
Zip Code
90502
Ikegami, Machiko; Dhami, Rajwinder; Schuchman, Edward H (2003) Alveolar lipoproteinosis in an acid sphingomyelinase-deficient mouse model of Niemann-Pick disease. Am J Physiol Lung Cell Mol Physiol 284:L518-25
Glasser, Stephan W; Detmer, Emily A; Ikegami, Machiko et al. (2003) Pneumonitis and emphysema in sp-C gene targeted mice. J Biol Chem 278:14291-8
Gurel, O; Ikegami, M; Chroneos, Z C et al. (2001) Macrophage and type II cell catabolism of SP-A and saturated phosphatidylcholine in mouse lungs. Am J Physiol Lung Cell Mol Physiol 280:L1266-72
Kramer, B W; Jobe, A H; Ikegami, M (2001) Exogenous surfactant changes the phenotype of alveolar macrophages in mice. Am J Physiol Lung Cell Mol Physiol 280:L689-94
Rider, E D; Ikegami, M; Pinkerton, K E et al. (2000) Lysosomes from rabbit type II cells catabolize surfactant lipids. Am J Physiol Lung Cell Mol Physiol 278:L68-74
Ikegami, M; Whitsett, J A; Chroneos, Z C et al. (2000) IL-4 increases surfactant and regulates metabolism in vivo. Am J Physiol Lung Cell Mol Physiol 278:L75-80
Elhalwagi, B M; Zhang, M; Ikegami, M et al. (1999) Normal surfactant pool sizes and inhibition-resistant surfactant from mice that overexpress surfactant protein A. Am J Respir Cell Mol Biol 21:380-7
Jobe, A H; Ikegami, M (1998) Surfactant homeostasis in corticotropin-releasing hormone deficiency in adult mice. Am J Respir Crit Care Med 158:995-7
Ikegami, M; Korfhagen, T R; Whitsett, J A et al. (1998) Characteristics of surfactant from SP-A-deficient mice. Am J Physiol 275:L247-54
Ikegami, M; Horowitz, A D; Whitsett, J A et al. (1998) Clearance of SP-C and recombinant SP-C in vivo and in vitro. Am J Physiol 274:L933-9

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