Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
5R37HL015696-23
Application #
2214897
Study Section
Special Emphasis Panel (NSS)
Project Start
1976-05-01
Project End
1997-04-30
Budget Start
1995-05-01
Budget End
1997-04-30
Support Year
23
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Emory University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Jideama, N M; Noland Jr, T A; Raynor, R L et al. (1996) Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties. J Biol Chem 271:23277-83
Wang, S Y; Feelisch, M; Harrison, D G et al. (1996) Preferential dilation of large coronary microvessels by the mononitrates SPM-4744 and SPM-5185. J Cardiovasc Pharmacol 27:587-93
Noland Jr, T A; Raynor, R L; Jideama, N M et al. (1996) Differential regulation of cardiac actomyosin S-1 MgATPase by protein kinase C isozyme-specific phosphorylation of specific sites in cardiac troponin I and its phosphorylation site mutants. Biochemistry 35:14923-31
Harrison, D G; Ohara, Y (1995) Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: implications for impaired vasomotion. Am J Cardiol 75:75B-81B
Ohara, Y; Sayegh, H S; Yamin, J J et al. (1995) Regulation of endothelial constitutive nitric oxide synthase by protein kinase C. Hypertension 25:415-20
Noland Jr, T A; Guo, X; Raynor, R L et al. (1995) Cardiac troponin I mutants. Phosphorylation by protein kinases C and A and regulation of Ca(2+)-stimulated MgATPase of reconstituted actomyosin S-1. J Biol Chem 270:25445-54
Ohara, Y; Peterson, T E; Zheng, B et al. (1994) Lysophosphatidylcholine increases vascular superoxide anion production via protein kinase C activation. Arterioscler Thromb 14:1007-13
Venema, R C; Raynor, R L; Noland Jr, T A et al. (1993) Role of protein kinase C in the phosphorylation of cardiac myosin light chain 2. Biochem J 294 ( Pt 2):401-6
Venema, R C; Kuo, J F (1993) Protein kinase C-mediated phosphorylation of troponin I and C-protein in isolated myocardial cells is associated with inhibition of myofibrillar actomyosin MgATPase. J Biol Chem 268:2705-11
Noland Jr, T A; Kuo, J F (1993) Phosphorylation of cardiac myosin light chain 2 by protein kinase C and myosin light chain kinase increases Ca(2+)-stimulated actomyosin MgATPase activity. Biochem Biophys Res Commun 193:254-60

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