The proposed program is focused on mechanisms of transport of small solutes from the blood into the myocardium and in particular on the characterization of transport across the capillary wall, via trans- and inter-endothelial cell routes. Previous work has gone a long way in obtaining clear mathematical descriptions of intravascular and transcapillary transport. The new emphasis is on the mechanisms of transport, particularly for fatty acids and adenosine into or across endothelial cells via facilitated or passive mechanisms. The multiple indicator dilution technique will be used to evaluate the unidirectional plasmalemmal fluxes of adenosine and fatty acids. Specific experiments will be done to test the hypothesis that the membrane transporters for adenosine and inosine can behave as facilitating countertransporters, that is, show augmentation of cis to trans flux by raising the trans-concentrations. The program should result in proven new techniques for estimating fluxes across endothelial cell walls in intact organs and provide data on specific solutes in the myocardium of dogs and rabbits.
| Yipintsoi, Tada; Kroll, Keith; Bassingthwaighte, James B (2016) Fractal regional myocardial blood flows pattern according to metabolism, not vascular anatomy. Am J Physiol Heart Circ Physiol 310:H351-64 |
| Bassingthwaighte, James B; Raymond, Gary M; Butterworth, Erik et al. (2010) Multiscale modeling of metabolism, flows, and exchanges in heterogeneous organs. Ann N Y Acad Sci 1188:111-20 |
| Bassingthwaighte, James B (2008) Linking cellular energetics to local flow regulation in the heart. Ann N Y Acad Sci 1123:126-33 |
| Kellen, Michael R; Bassingthwaighte, James B (2003) Transient transcapillary exchange of water driven by osmotic forces in the heart. Am J Physiol Heart Circ Physiol 285:H1317-31 |
| Bassingthwaighte, J B; Beard, D A; Li, Z (2001) The mechanical and metabolic basis of myocardial blood flow heterogeneity. Basic Res Cardiol 96:582-94 |
| Schwartz, L M; Bukowski, T R; Ploger, J D et al. (2000) Endothelial adenosine transporter characterization in perfused guinea pig hearts. Am J Physiol Heart Circ Physiol 279:H1502-11 |
| Schwartz, L M; Bukowski, T R; Revkin, J H et al. (1999) Cardiac endothelial transport and metabolism of adenosine and inosine. Am J Physiol 277:H1241-51 |
| Bassingthwaighte, J B (1997) Design and strategy for the Cardionome Project. Adv Exp Med Biol 430:325-39 |
| King, R B (1996) Modeling membrane transport. Adv Food Nutr Res 40:243-62 |
| Stapleton, D D; Moffett, T C; Baskin, D G et al. (1995) Autoradiographic assessment of blood flow heterogeneity in the hamster heart. Microcirculation 2:277-82 |
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