Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
7R37HL036061-21
Application #
7213738
Study Section
Special Emphasis Panel (NSS)
Project Start
1985-09-01
Project End
2008-08-31
Budget Start
2006-04-01
Budget End
2008-08-31
Support Year
21
Fiscal Year
2004
Total Cost
$70,501
Indirect Cost
Name
University of Rochester
Department
Pathology
Type
Schools of Dentistry
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Giddings, Kara S; Zhao, Ji; Sims, Peter J et al. (2004) Human CD59 is a receptor for the cholesterol-dependent cytolysin intermedilysin. Nat Struct Mol Biol 11:1173-8
Sims, P J; Wiedmer, T (2001) Unraveling the mysteries of phospholipid scrambling. Thromb Haemost 86:266-75
Zhao, X J; Zhao, J; Zhou, Q et al. (1998) Identity of the residues responsible for the species-restricted complement inhibitory function of human CD59. J Biol Chem 273:10665-71
Christiansen, V J; Sims, P J; Hamilton, K K (1997) Complement C5b-9 increases plasminogen binding and activation on human endothelial cells. Arterioscler Thromb Vasc Biol 17:164-71
Husler, T; Lockert, D H; Sims, P J (1996) Role of a disulfide-bonded peptide loop within human complement C9 in the species-selectivity of complement inhibitor CD59. Biochemistry 35:3263-9
Petranka, J; Zhao, J; Norris, J et al. (1996) Structure-function relationships of the complement regulatory protein, CD59. Blood Cells Mol Dis 22:281-96
Zhou, Q; Zhao, J; Husler, T et al. (1996) Expression of recombinant CD59 with an N-terminal peptide epitope facilitates analysis of residues contributing to its complement-inhibitory function. Mol Immunol 33:1127-34
Rother, R P; Zhao, J; Zhou, Q et al. (1996) Elimination of potential sites of glycosylation fails to abrogate complement regulatory function of cell surface CD59. J Biol Chem 271:23842-5
Lockert, D H; Kaufman, K M; Chang, C P et al. (1995) Identity of the segment of human complement C8 recognized by complement regulatory protein CD59. J Biol Chem 270:19723-8
Husler, T; Lockert, D H; Kaufman, K M et al. (1995) Chimeras of human complement C9 reveal the site recognized by complement regulatory protein CD59. J Biol Chem 270:3483-6

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