Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Method to Extend Research in Time (MERIT) Award (R37)
Project #
3R37HL038216-02S1
Application #
3486176
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1988-04-01
Project End
1992-03-31
Budget Start
1988-05-01
Budget End
1989-03-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
Tufts University
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02111

  Publications

Czerwiec, Eva; Begley, Gail S; Bronstein, Mila et al. (2002) Expression and characterization of recombinant vitamin K-dependent gamma-glutamyl carboxylase from an invertebrate, Conus textile. Eur J Biochem 269:6162-72
Falls, L A; Furie, B; Furie, B C (2000) Role of phosphatidylethanolamine in assembly and function of the factor IXa-factor VIIIa complex on membrane surfaces. Biochemistry 39:13216-22
Begley, G S; Furie, B C; Czerwiec, E et al. (2000) A conserved motif within the vitamin K-dependent carboxylase gene is widely distributed across animal phyla. J Biol Chem 275:36245-9
Bush, K A; Stenflo, J; Roth, D A et al. (1999) Hydrophobic amino acids define the carboxylation recognition site in the precursor of the gamma-carboxyglutamic-acid-containing conotoxin epsilon-TxIX from the marine cone snail Conus textile. Biochemistry 38:14660-6
Furie, B; Bouchard, B A; Furie, B C (1999) Vitamin K-dependent biosynthesis of gamma-carboxyglutamic acid. Blood 93:1798-808
Gillis, S; Furie, B C; Furie, B et al. (1997) gamma-Carboxyglutamic acids 36 and 40 do not contribute to human factor IX function. Protein Sci 6:185-96
Furie, B C; Ratcliffe, J V; Tward, J et al. (1997) The gamma-carboxylation recognition site is sufficient to direct vitamin K-dependent carboxylation on an adjacent glutamate-rich region of thrombin in a propeptide-thrombin chimera. J Biol Chem 272:28258-62
Rigby, A C; Baleja, J D; Li, L et al. (1997) Role of gamma-carboxyglutamic acid in the calcium-induced structural transition of conantokin G, a conotoxin from the marine snail Conus geographus. Biochemistry 36:15677-84
Rigby, A C; Baleja, J D; Furie, B C et al. (1997) Three-dimensional structure of a gamma-carboxyglutamic acid-containing conotoxin, conantokin G, from the marine snail Conus geographus: the metal-free conformer. Biochemistry 36:6906-14
Bristol, J A; Ratcliffe, J V; Roth, D A et al. (1996) Biosynthesis of prothrombin: intracellular localization of the vitamin K-dependent carboxylase and the sites of gamma-carboxylation. Blood 88:2585-93

Showing the most recent 10 out of 24 publications